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  UPCOMING EVENTS   Selected Seminar        
Date: 22 August 2017
Time: 11:00am | Level 3, IMCB Seminar Room 3-46, Proteos
Speaker: A/Prof. Uttiya Basu
Title: Two genomic elements in conflict during IgH chromosomal rearrangement in B cells

Recently, the mechanisms by which non-coding RNAs (ncRNAs) affect genomic integrity have become a topic of intense interest.  Researchers increasingly are focusing on intergenic and intragenic enhancers found inside superenhancer regulatory elements, encoding various types of enhancer RNAs (eRNAs). Although the eRNAs expressed from these superenhancer sequences are implicated in the promotion of enhancer function and gene regulation, the flip side of this process is chromosomal instability caused by secondary DNA structure formation, non-coding RNA associated DNA/RNA hybrid formation, and potential collisions of transcription complexes with replisomes. It is revealing that many chromosomal aberrations, some associated with malignancies, are present inside enhancer sequences.  Focusing specifically on the role of the eRNA transcription and processing, we wish to expand on current concepts to understand better both the generation of these ncRNAs and their role in the maintenance of genomic integrity.  We study the concepts of chromatin marks defining regions of eRNA expression, the role RNA exosome, among other factors, plays in the expression control of eRNAs, and how enhancers may be transcriptionally silenced by mechanisms that depend upon processing or bidirectional transcription that exist at these loci. In this presentation, I plan to discuss the identification, function and organization of a enhancer RNA expressing genomic cluster, that regulates Immunoglobulin heavy chain locus by mechanisms that are novel and open to discussion.

Uttiya Basu received his Ph.D. degree in Molecular Biology from Albert Einstein College of Medicine in 2004. After finishing postdoctoral training in the laboratory of Dr. Frederick Alt at Harvard Medical School in 2009, he joined the faculty of Columbia University, Department of Microbiology and Immunology. His laboratory utilizes technologies involving genome engineering, genomics and biochemistry. His research is focused on the various mechanisms by which non-coding RNA transcription controls genome architecture in pluripotent and differentiated mammalian cells. He has been awarded the NIH director’s New Innovators Award, the Leukemia Lymphoma Society Career Development award,The Pershing Square Sohn Cancer Research Alliance prize, Irvington Institute and Cancer research institute post doctoral fellowship and Lymphoma Research Foundation Award for cancer research.

Host: Prof. Vinay Tergaonkar

Seminar is open to public, registration is not required.


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