Yue WANG    
                       
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  Publications  
 

Yue Wang (2016).
Hgc1-Cdc28—how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?
J Microbiol 54: 170-177.

HT Wang, Zhenxing Huang, Hao Zou, Guisheng Zeng, Jie Ying Au Yong, Jiaxin Gao, Yanming Wang, Ada Wong, and Yue Wang (2016).
CDK phosphorylates the polarisome scaffold Spa2 to maintain its localization at the site of cell growth.
Mol Microbiol 101:250-264.

QZ Liu, Qi Han, GY Yao, N Wang, GS Zeng, YM Wang, ZX Huang, JiL Sang and Yue Wang  (2016).
Tpd3-Pph21 phosphatase plays a direct role in Sep7 dephosphorylation in Candida albicans.
Mol Microbiol 101:109-121.

JY Au Yong, YM Wang and Yue Wang (2016).
The Nim1 kinase Gin4 has distinct domains crucial for septin assembly, phospholipid binding and mitotic exit.
J Cell Sci doi: 10.1242/jcs.183160.

GY Yao, JH Wan, CH Mu, QZ Liu, Yue Wang* and JL Sang* (*corresponding authors) (2016). Sds22 participates in Glc7 mediated Rad53 dephosphorylation in MMS-induced DNA damage in Candida albicans.
Fungal Genet Biol 93: 50-61.

CJ Seneviratne, GS Zeng, T Truong, SSW Wong , L Samaranayake, FY Chan, YM Wang, H Wang, J Gao and Yue Wang (2015).
New “haploid biofilm model” unravels IRA2 as a novel regulator of Candida albicans biofilm formation.
Scientific Reports 5, Article number: 12433 doi:10.1038/srep12433

GB Guan, HT Wang, WH Liang, CJ Cao, S  Naseem, JB Konopka, Yue Wang and GH Huang (2015).
The mitochondrial protein Ngu1 plays important roles in carbon source utilization, filamentation, and virulence in Candida albicans.
Fungal Genet Biol S1087-1845(15)00009-2. doi: 10.1016/j.fgb.2015.01.006.

JHJ Lim, S Ravikumar, YM Wang, T Thamboo, L Ong, JM Chen, JG Goh, F Tay, L Chengchen, MS Win, W Leong, T Lau, R Foo, K Tan, S Sethi, AL Khoo, WJ Chng, O Motomi, M Netea, Y Wang, L Chai (2015).
Bimodal Influence of vitamin D in Host response to candida Infection – vitamin D Dose Matters
Journal of Infectious Disease  pii: jiv033.

JA Greig, IM Sudbery, JP Richardson, JR Naglik, Y Wang*, PE Sudbery*(*corresponding author) (2015)
Cell Cycle-Independent Phospho-Regulation of Fkh2 during Hyphal Growth Regulates Candida albicans Pathogenesis
PLOS Pathog 11(1):e1004630.

JX Gao, HT Wang, AHH Wong, GS Zeng, ZX Huang, YM Wang, JL Sang, and Yue Wang (2014).
Regulation of Rfa2 phosphorylation in response to genotoxic stress in Candida albicans.
Mol Micriobiol  94: 141-55.

ZX Huang, HT Wang, YM Wang, Yue Wang (2014).
A Novel Mechanism Coupling cAMP-PKA Signaling and Golgi Traffic via Gyp1 Phosphorylation During Polarized Growth.
Eukaryot cell 13: 1548-56.

GS Zeng, YM Wang, FY Chang, and Y Wang (2014).
One-step targeted gene deletion in Candida albicans haploids..

Nature Protocols 9: 464-73.

ZX Huang, P Zhao, GS Zeng, YM Wang, I Sudbery, P Sudbery, and Yue Wang (2013).
Nap1 regulates the septin ring dynamics and morphogenesis in Candida albicans.

mBio
5(1): e00915-13.

Y Wang (2013).
Fungal adenylyl cyclase acts as a signal sensor and integrator and plays a central role in interaction with bacteria.
Plos Pathog
9(10): e1003612.


MA Hickman, G Zeng, A Forche, MP Hirakawa, D Abbey, BD Harrison, YM Wang, CH Su, RJ Bennett, Y Wang, J Berman. (2013).
The 'obligate diploid' Candida albicans forms mating-competent haploids.
Nature 494: 55-59.
           
H Wang, J Gao, AH Wong, K Hu, W Li, Y Wang, and J Sang. (2013).
Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans.
Biochem J 449: 673-681.

KD Hu, WJ Li, HT Wang, K Chen, Y Wang*, JL Sang* (2012).
Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans. (*Co-orresponding author).
Fungal Genet Biol 49: 433-442.
           
HT Wang, JX Gao, WJ Li, AHH Wong, KD Hu, K Chen, Y Wang* and JL Sang*. (2012).
Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans. (*Co-corresponding author).
PLoS One 7: e37246.

GS Zeng, YM Wang, and Y Wang (2012).
Cdc28−Cln3 regulates actin-mediated endocytosis by targeting Sla1 in different modes of fungal growth.
Mol Biol Cell 23: 3485-3497.

HT Wang, JX Gao, AHH Wong, KD Hu, WJ Li, Y Wang* and JL Sang* (2012).
Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans. (*Co-corresponding author).
Biochem J 2012 Nov 9. [Epub ahead of print]

CR Li, YM Wang, JY Au Yong, and Y Wang (2012).
CDK Regulates Septin Dynamics through Cell-cycle-dependent Phosphorylation of the Nim1 Kinase Gin4.
J Cell Sci
24 Feb [Epub ahead of print] PMID: 22366454.

C Bai, XL Xu, HS Wang, YM Wang, FY Chan, Y Wang (2011).
Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans.
Mol Microbiol  82: 879-893.

LL Sun, WJ Li, J Chen, HT Wang, P Deng, Y Wang, and JL Sang (2011).
The protein phosphatase Pph3 and its regulatory subunit Psy2 regulate Rad53 dephosphorylation and cell morphogenesis during recovery from DNA damage in Candida albicans.
Eukaryotic Cell 10:1565-1573.

P Gutiérrez-Escribano, A González-Novo, B Suárez, CR Li, Y Wang, CR Vázquez de Aldana and J Correa-Bordes (2011).
Cdk-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans.
Mol Biol Cell 22: 2458-2469.

RA Hall, L De Sordi, DM MacCallum, H Topal, R Eaton, JW Bloor, GK. Robinson, LR Levin, J Buck, Y Wang, NAR Gow, C Steegborn, and FA Mühlschlegel (2010).
CO2 acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
PLoS Pathog 6(11): e1001193

Y Wang, H Zou, HM Fang, and Y Zhu (2010).
Linking cellular actin status with cAMP signaling in Candida albicans.
Virulence 1:.202-205.

H Zou, HM Fang, Y Zhu, and Y Wang (2009).
Candida albicans Cyr1, Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growth.
Mol Microbiol Nov 25. [Epub ahead of print]

Y Wang (2009).
CDKs and the yeast-hyphal decision.
Curr Opin Microbiol 12:644-649.

Y Zhu, HM Fang, YM Wang, GS Zeng, XD Zheng, Y Wang (2009).
Ras1 and Ras2 play antagonistic roles in regulating cellular cAMP level, stationary-phase entry and stress response in Candida albicans.
Mol Microbiol 74:862-875.

CR Li, YM Wang, and Y Wang (2008).
The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.
EMBO J 27: 2998–3010

Y Wang and XL Xu. (2008).
Bacterial peptidoglycan-derived molecules activate Candida albicans hyphal growth.
Communicative & Integrative Biology 1:2, 1-3.

TT Zhang, D Li, WJ Li, Y Wang* and JL Sang (2008). (*co-corresponding author).
CaSfl1 plays a dual role in transcriptional regulation in Candida albicans.
Sci China C Life Sci 53:2624-2631

XL Xu, RTH Lee, HM Fang, YM Wang, R Li, H Zou, Y Zhu and Y Wang. (2008).
Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Cell Host & Microbe 4:28-39. (Cover story)

T Zhang, W Li, D Li, Y Wang, and J Sang. (2008).
Role of CaECM25 in cell morphogenesis, cell growth and virulence in Candida albicans.
Sci China C Life Sci 51:362-372.

R Jureen, TH Koh, G Wang, LYA Chai, AL Tan, TChai, YW Wong, Y Wang, PA Tambyah, Roger Beuerman and D Tan. (2008).
Use of multiple methods for genotyping Fusarium during an outbreak of contact lens associated fungal keratitis in Singapore.
BMC Infect Dis 8: 91

XD Zheng, RTH Lee, YM Wang, QS Lin and Y Wang (2007).
Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth.
EMBO J
26: 3760-3769.

I Sinha, YM Wang, R Philp, CR Li, and Y Wang (2007).
Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.
Dev Cell 13:421-432.

YAL Chai, Y Wang, AL Khoo, FY Chan, C Chow, G Kumarsinghe, K Singh and PA Tambyah (2007).
Predominance of Candida Tropicalis bloodstream infections in a Singapore teaching hospital.
Med Mycology 45:435-439.

CR Li, RTH Lee, YM Wang, XD Zheng, and Y Wang (2007).
Septin ring formation separates Candida albicans hyphal development into Sec3p-independent and dependent phases.
J Cell Sci 120:1898-1907.

QM Shi, YM Wang, XD Zheng, RTH Lee, and Y Wang (2007).
Critical Role of DNA Checkpoints in Mediating Genotoxic-Stress-induced Filamentous Growth in Candida albicans.
Mol Biol Cell 18:815-826.

WJ Li, XD Zheng, YM Wang, and Y Wang (2006).
The F-box protein Grr1 regulates the stability of Cln1, Cln3 and Hof1 and cell morphogenesis in Candida albicans. Mol Microbiol 62:212-226.

CF Chou, CB Loh, YK Foo, S Shen, BC Fielding, TH Tan, S Khan, Y Wang, SG Lim, W Hong, YJ Tan, J Fu (2006). ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus).
Gene
377:46-55.

HM Fang, and Y Wang (2006).
RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.
Mol Microbiol
61:484-496.

) C Bai, XL Xu, FY Chang, RTH Lee, and Y Wang (2006).
MNN5 encodes an iron-regulated α-1,2-mannosyltransferase important for protein glycosylation, cell wall integrity, morphogenesis and virulence in Candida albicans.
Eukaryot Cell
5:238-247.

X Tan, A Peng, YC Wang, Y Wang, and QY Sun (2005).
Participation of the ubiquitin-proteasome pathway in rat oocyte activation.
Zygote 13:87-95.

CR Li, YM Wang, XD Zheng, HY Liang, JCW Tang and Y Wang (2005).
The formin family protein CaBni1p has a role in cell polarity control during both yeast and hyphal growth in Candida albicans.
J Cell Sci
118:2637-2648.

B Chen, YC Fong and Y Wang (2005).
Identification and functional characterization of a novel Candida albicans gene CaMNN5 that suppresses the iron-dependent growth defect of Saccharomyces cerevisiae aft1Δ mutant.
Biochem J 389:27-35.

XD Zhang, YM Wang and Y Wang (2004).
Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.
EMBO J 23:1845-1856.

XD Zheng, YM Wang and Y Wang (2003).
CaSPA2 is important for polarity establishment and maintenance in Candida albicans.
Mol Microbiol
49:1391-1405.

CW Yang, TMS Barkham, FY Chan and Y Wang (2003).
Prevalence of Candida Species including Candida dubliniensis in Singapore.
J Clin Microbiol
41:472-474.

HM Fang and Y Wang (2002).
Characterization of iron binding motifs in Candida albicans high-affinity iron permease CaFtr1p by site-directed mutagenesis.
Biochem J 368:641-647.

CJ Hu, C Bai, XD Zhang, YM Wang and Y Wang (2002).
Characterization and Functional Analysis of the Siderophore-Iron Transporter CaArn1p in Candida albicans.
J Biol Chem 277:30598-30605.

S Brenner, B Venkatesh, WH Yap, SF Chou, A Tay, S Ponniah, Y Wang and YH Tan (2002).
Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals.
Proc Natl Acad Sci (USA) 99:2936-2941.

HS Wang, SL Yeo, J Xu, XL Xu, H He, F Ronca, Anthony E. Ting, Y Wang, VC Yu, MM Sim (2002).
Isolation of Streptonigrin and Its Novel Derivative from Micromonospora as Inducing Agents of p53-dependent Cell Apoptosis.
J Nat Prod
65:721-724.

C Bai, N Ramanan, YM Wang and Y Wang (2002).
The mitotic spindle checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice.
Mol Microbiol 45:32-44.

ZS Zhang, T Kudo, Y Nakajima and Y Wang (2001).
Clarification of the relationship of the members of the family Thermomonosporaceae on the basis of 16S rDNA, 16S-23S rRNA internal transcribed spacer and 23S rDNA sequences and chemotaxonomic analyses.
Int J Syst Evol Microbiol 51:373-383.

YM Wang, ZS Zhang, XL Xu, JS Ruan and Y Wang (2001).
Actinpolymorpha singaporensis gen. nov. sp. nov., a novel actinomycete from the tropical rainforest of Singapore. Int J Syst Evol Microbiol 51:467-473.

H Wang, KL Lim, SL Yeo, X Xu, MM Sim, AE Ting, Y Wang, SYee, YH Tan, and CJ Pallen (2000).
Isolation of a novel protein tyrosine phosphatase inhibitor, 2-Methyl-Fervenulone, and its precursors from Streptomyces.
J Nat Prod 63:1641-1646.

Y Wang and ZS Zhang (2000).
Comparative sequence analyses reveal frequent occurrence of short segments containing an abnormally high number of non-random base variations in bacterial rRNA genes.
Microbiology 146:2845-2854.

L Zhang, T Lee, TW Soong and Y Wang (2000).
Heterologous expression, functional characterization of two monkey iron transporter Nramp2.
Biochem J 349:289-297.

R Narendrakumar and Y Wang (2000).
A high affinity iron permease essential for Candida albicans virulence.
Science
288:1062-1064.

TW Soong, YD Fong, R Narendrakumar and Y Wang (2000).
Candida albicans
Na/H antiporter has a role in pH sensing, salt tolerance, morphogenesis and pathogenesis. Microbiology 146:1035-1044.

Y Wang, ZS Zhang, JS Ruan, YM Wang, SM Ali, WL Tan, CL Lee and GN Koh (1999).
High Actinomycete Diversity in the Tropical Rainforests of Singapore.
In Microbial Diversity in Asia—Technology and Prospects. World Scientific Publishing Ltd., Singapore, USA and Tokyo.

W H Yap, ZS Zhang, and Y Wang (1999).
Two distinct types of rRNA operons exist in the genome of the thermophilic actinomycete Thermomonospora chromogena, evidence for lateral transfer of an entire rRNA operon. J Bacteriol 181:5201-5209.

Y Wang, ZS Zhang, YM Wang and SM Ali (1999).
Investigation of actinomycete diversity in the tropical rainforests of Singapore.
J Industrial Microbiol & Biotech 23:178-187.

WH Yap and Y Wang (1999).
Molecular cloning and comparative sequence analysis of rRNA operons in Streptomyces nodusus ATCC14899.
Gene 232:77-85.

WQ Xiao, SQ Zhang, YC Wang and Y Wang (1999).
Partial inhibition of CDK4 gene expression leads to the extension of G1 phase of V79-8 cells.
Chinese Science Bulletin
44:149-153.

ZS Zhang, JS Ruan and Yue Wang (1998).
Reclassification of Thermomonospora and Microtetraspora.
Intl J Syst Bacteriol 48:411-422.

GCY Wang and Y Wang. (1997).
Frequency of thr formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes.
Appl Environ Microbiol
63:4645-4650.

ZS Zhang, JS Ruan and Y Wang. (1997).
A proposal to revive the genus Kitasatospora (Omura 1982).
Intl J Syst Bacteriol 47:1048-1054.

Y Wang, ZS Zhang, and R Narendrakumar. (1997).
The actinomycete Thermobispora contains two distinct types of transcriptionally active 16S rRNA genes.
J Bacteriol
179:3270-3276.

KL Lim, DSY Lai, MB Kalousek, Y Wang and CJ Pallen. (1997).
Kinetic analysis of two closely related receptor-like protein tyrosine phosphatases, PTP alpha and PTP epsilon.
Euro J Biochem 245:693-700.

Y Wang, ZS Zhang and JS Ruan (1996).
A proposal to transfer Microbispora Bispora (Lechevalier 1965) to a new genus Thermobispora gen. nov. as Thermobispora bispora comb. nov.
Intl J Syst Bacteriol
46:933-938.

Y Wang, ZS Zhang and JS Ruan (1996).
Phylogenetic analysis revealed new relationships among members of the genera Microbispora and Microtetraspora.
Intl J Syst Bacteriol
46:658-663.

GCY Wang and Y Wang (1996).
The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species.
Microbiology 142:1107-1114.

GCY Wang and Y Wang (1995).
Rapid differentiation of bacterial species with multiple probes of different lengths in a single slot-blot hybridization.
Appl Environ Microbiology
61:4269-4273.

M Feng, HX Zhang, YC Wang and Y Wang (1994).
MPF induction of microtubule assembly at interphase kinetochore of CHO Cells.
Dev Reprod Biol 3:11-16.

Y Wang and GCY Wang (1993).
A Molecular approach to the investigation of microbial diversity. p276-285. In Sim Tiow and Mukit Singh (ed.) Microbiology in the Nineties.
Proceedings of the Third SSM International Congress on Microbiology in the Nineties.

CJ Pallen, Y Wang and XM Zheng (1993).
Structure and function of the receptor-like protein tyrosine phosphatase HPTPα.
Advances in Phosphatases
7:439-456.

XM Zheng, Y Wang and CJ Pallen (1992).
Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase.
Nature
359:336-338.

Y Wang and CJ Pallen (1992).
Expression and characterization of wild type, truncated, and mutant forms of the intracellular region of the receptor-like protein tyrosine phosphatase HPTPβ.
J Biol Chem 267:16696-16702.

Y Wang and CJ Pallen (1991).
The human receptor-like protein tyrosine phosphatase HPTPα has two active domains with distinct substrate specificity.
EMBO J
10:3231-3237.

Y Wang and B Van Ness (1989).
Site-specific cleavage of supercoiled DNA by ascorbate/Cu(II).
Nucl Acid Res
17:6915-6929.

Y Wang and W Sauerbier (1989).
Interaction between structure transitions in a torsionally constrained DNA.
Biochem Biophys Res Com
158: 696-704.

Y Wang and W Sauerbier (1989).
Flanking AT-Rich sequences may lower the activation energy of cruciform extrusion in supercoiled DNA.
Biochem Biophys Res Com
158:423-433.

Y Wang and W Sauerbier (1987).
pUC12-W1: A Plasmid for the study of cloned DNA conformation.
Gene
60:303-306.

Y Wang and W Sauerbier (1987).
Mapping structurally perturbed sites in DNA by replication arrest and run-off replication.
Biochem Biophys Res Com
146:1523-1530.

 
  Patents and Licenses  
 

CJ Pallen, XM Zheng, and Y Wang.
PTPa as diagnostic or prognostic marker.
(EP 0 764 272, US Patent No.5888746).

CJ Pallen, HS Wang, KL Lim, S L Yeo, Y Wang, YH Tan.
Novel Protein Tyrosine Phosphatase inhibitor
Singapore 95307 / 200301067-5.

CJ Pallen, HS Wang, KL Lim, S L Yeo, Y Wang, YH Tan.
Novel Protein Tyrosine Phosphatase inhibitor (US)
7,199.121 B2.

Y Wang, Xl Xu and RTH Lee.
Modulators of Candida Hyphal Morphogenesis and Uses Thereof.
ETPL Ref: IMC/P/04364/00/US Provisional filing in US, 25 August 2006.

Y Wang.
Actinomycetes collection for use in drug discovery.
Licensee: Merlion Pharmaceuticals Pte. Ltd. Licensing period: Sept 2003 to Aug 2006.

Y Wang.
Actinomycetes Collection for use in drug discovery.
Licensee: Merlion Pharmaceuticals Pte. Ltd. Licensing period: Sept 2006 to Aug 2009.
 
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