Yue WANG    
                       
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  Yue WANG  
  Lab Location: #6-17

email:
mcbwangy@imcb.a-star.edu.sg
tel:65869521
 
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  Key Publications  
 

 

CJ Seneviratne, GS Zeng, T Truong, SSW Wong , L Samaranayake, FY Chan, YM Wang, H Wang, J Gao and Yue Wang (2015).
New “haploid biofilm model” unravels IRA2 as a novel regulator of Candida albicans biofilm formation.
Scientific Reports 5, Article number: 12433 doi:10.1038/srep12433

JA Greig, IM Sudbery, JP Richardson, JR Naglik, Y Wang*, PE Sudbery*(*corresponding author) (2015)
Cell Cycle-Independent Phospho-Regulation of Fkh2 during Hyphal Growth Regulates Candida albicansPathogenesis
PLOS Pathog 11(1):e1004630.

JX Gao, HT Wang, AHH Wong, GS Zeng, ZX Huang, YM Wang, JL Sang, and Yue Wang (2014). Regulation of Rfa2 phosphorylation in response to genotoxic stress in Candida albicans.
Mol Micriobiol  94: 141-55.

GS Zeng, YM Wang, FY Chang, and Y Wang (2014).
One-step targeted gene deletion in Candida albicans haploids..

Nature Protocols 9: 464-73.

ZX Huang, P Zhao, GS Zeng, YM Wang, I Sudbery, P Sudbery, and Yue Wang (2013).
Nap1 regulates the septin ring dynamics and morphogenesis in Candida albicans.

mBio  5(1): e00915-13.

Y Wang (2013).
Fungal adenylyl cyclase acts as a signal sensor and integrator and plays a central role in interaction with bacteria.
Plos Pathog
9(10): e1003612

MA Hickman, G Zeng, A Forche, MP Hirakawa, D Abbey, BD Harrison, YM Wang, CH Su, RJ Bennett, Y Wang, J Berman (2013).
The 'obligate diploid' Candida albicans forms mating-competent haploids..
Nature
494: 55-59.

GS Zeng, YM Wang, and Y Wang (2012).
Cdc28-Cln3 regulates actin-mediated endocytosis by targeting Sla1 in different modes of fungal growth.
Mol Biol Cell
23: 3485-3497.

CR Li, YM Wang, JY Au Yong, and Y Wang (2012).
CDK Regulates Septin Dynamics through Cell-cycle-dependent Phosphorylation of the Nim1 Kinase Gin4.
J Cell Sci
24 Feb [Epub ahead of print] PMID: 22366454.

C Bai, XL Xu, HS Wang, YM Wang, FY Chan, Y Wang (2011).
Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans.
Mol Microbiol  82: 879-893.

H Zou, HM Fang, Y Zhu, and Y Wang (2009).
Candida albicans Cyr1, Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growth.
Mol Microbiol Nov 25. [Epub ahead of print]

Y Wang (2009)
CDKs and the yeast-hyphal decision.
Curr Opin Microbiol 12:644-649.

Y Zhu, HM Fang, YM Wang, GS Zeng, XD Zheng, Y Wang (2009).
Ras1 and Ras2 play antagonistic roles in regulating cellular cAMP level, stationary-phase entry and stress response in Candida albicans.
Mol Microbiol 74:862-875.

CR Li, YM Wang, and Y Wang (2008)
The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.
EMBO J 27: 2998–3010

XL Xu, RTH Lee, HM Fang, YM Wang, R Li, H Zou, Y Zhu and Y Wang. (2008).
Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Cell Host & Microbe 4:28-39. (Cover story)

XD Zheng, RTH Lee, YM Wang, QS Lin and Y Wang (2007). Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth.
EMBO J 26: 3760-3769.

I Sinha, YM Wang, R Philp, CR Li, WH Yap and Y Wang (2007). Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.
Dev Cell 13:421-432.

CR Li, RTH Lee, YM Wang, XD Zheng, and Y Wang (2007). Septin ring formation separates Candida albicans hyphal development into Sec3p-independent and dependent phases.
J Cell Sci
120:1898-1907.

QM Shi, YM Wang, XD Zheng, RTH Lee, and Y Wang (2007). Critical Role of DNA Checkpoints in Mediating Genotoxic-Stress-induced Filamentous Growth in Candida albicans.
Mol Biol Cell
18:815-826.

WJ Li, XD Zheng, YM Wang, and Y Wang (2006).
The F-box protein Grr1 regulates the stability of Cln1, Cln3 and Hof1 and cell morphogenesis in Candida albicans.
Mol Microbiol 62:212-226.

HM Fang, and Y Wang (2006).
RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.
Mol Microbiol
61:484-496.

CR Li, YM Wang, XD Zheng, HY Liang, JCW Tang and Y Wang (2005).
The formin family protein CaBni1p has a role in cell polarity control during both yeast and hyphal growth in Candida albicans.
J Cell Sci
118:2637-2648.

XD Zhang, YM Wang and Y Wang (2004).
Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.
EMBO J 23:1845-1856.

XD Zheng, YM Wang and Y Wang (2003).
CaSPA2 is important for polarity establishment and maintenance in Candida albicans.
Mol Microbiol 49:1391-1405.

CJ Hu, C Bai, XD Zhang, YM Wang and Y Wang (2002). Characterization and Functional Analysis of the Siderophore-Iron Transporter CaArn1p in Candida albicans.
J Biol Chem
277:30598-30605.

C Bai, N Ramanan, YM Wang and Y Wang (2002).
The mitotic spindle checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice.
Mol Microbiol 45:32-44.

R Narendrakumar and Y Wang (2000).
A high affinity iron permease essential for Candida albicans virulence.
Science
288:1062-1064.

XM Zheng, Y Wang and CJ Pallen (1992).
Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature 359:336-338.

Y Wang and CJ Pallen (1992). Expression and characterization of wild type, truncated, and mutant forms of the intracellular region of the receptor-like protein tyrosine phosphatase HPTPβ. J Biol Chem 267:16696-16702.

Y Wang and CJ Pallen (1991). The human receptor-like protein tyrosine phosphatase HPTPα has two active domains with distinct substrate specificity.
EMBO J 10:3231-3237.

 
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    Yue WANG
 


Yue Wang obtained his PhD from the University of Minnesota in 1988 and then undertook postdoctoral research in the same university for one and a half years. In 1989, he joined IMCB as a postdoctoral research fellow. In 1993 he was promoted to senior scientist to lead a group in the study and utilization of equatorial microbial diversity for the discovery of novel bioactive compounds. His current research focus is on the study of the human fungal pathogen Candida albicans. Presently, he is a professor and research director. For his multiple ground breaking discoveries in the study of the virulence factors and basic biology of the human fungal pathogen Candida albicans, Dr Wang was awarded the President's Science Award 2012.

       
    Candida albicans Molecular & Cellular Biology
   


Infectious diseases are the leading cause of human death worldwide. Previously controllable pathogens are returning with higher virulence and unknown pathogens are emerging to cause new diseases. Drug-resistant ‘bugs’ have rendered many of our best antibiotics obsolete. The great challenge to medical science is to invent new ammunition with which to fight back.

Since the beginning of the AIDS pandemic about 25 years ago, the fungus Candida albicans, once an almost harmless commensal of human body, has rapidly become the most prevalent fungal pathogen. It often causes life-threatening systemic infections in immuno-compromised patients. This fungus is polymorphic and can switch between yeast, pseudohyphal and hyphal forms of growth in response to environmental cues. This property has strong links with its ability of infection. Dr. Yue Wang’s laboratory investigates the molecular mechanisms that control the growth transition, particularly how cells establish and maintain the highly polarized hyphal morphogenesis. In 2004, this laboratory found a key regulator, named Hgc1, of the yeast-hypha growth transition. The HGC1 deletion mutant grows constitutively in the yeast form and exhibits markedly reduced virulence. Hgc1 is a G1 cyclin-related protein and directly interacts with the master cell-cycle regulatory kinase Cdc28. In the past few years, this lab has identified a number of central components of the polarity machinery as direct substrates of the Hgc1-Cdc28 kinase, providing new insights into the molecular mechanisms that control polarized morphogensis in C. albicans.

C. albicans hyphal growth starts with the formation of a thin cell surface protrusion called germ tube. Similar structures are found in many cell types in diverse organisms, such as dendritic protrusions of neurons, root hairs and pollen tubes. Recent discoveries by Dr. Wang’s lab suggest that many aspects of the underlying mechanisms for polarized cell growth are evolutionarily conserved. This renders C. albicans a relevant model for addressing the fundamental biological issue of how cells establish and maintain polarity.