William F. BURKHOLDER / Stephen QUAKE / Yin Thai CHAN  
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  William F. BURKHOLDER  
  Lab Location: #3-04

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  Yin Thai CHAN  

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  Stephen QUAKE
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  Key Publications  

Wu, A.R., Hiatt, J.B., Lu, R., Attema, J.L., Lobo, N.A., Weissman, I.L., Clarke, M.F., and Quake, S.R. (2009). Automated microfluidic chromatin immunoprecipitation from 2,000 cells.
Lab Chip 9, 1365-1370.

Fan, H.C., Wang, J., Potanina, A., and Quake, S.R. (2011). Whole-genome molecular haplotyping of single cells. Nat Biotechnol 29, 51-57.

Maerkl, S.J., and Quake, S.R. (2007).
A systems approach to measuring the binding energy landscapes of transcription factors.
Science 315, 233-237.


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  The Microfluidics Systems Biology lab

The Microfluidics Systems Biology lab was established to address challenging questions related to cancer and developmental biology, infectious disease, and other areas of cell and molecular biology using cutting-edge microfluidic devices and novel applications of high-throughput DNA sequencing. The lab is focused on several project areas, which include:

1) genotyping single cells isolated from genetically heterogeneous populations such as tumors and microbial consortia
2) characterizing transcriptional and epigenetic regulation of gene expression by automated chromatin immunoprecipitation
3) mapping regulatory networks and macromolecular assemblies using high-throughput measurements of protein-protein and protein-DNA binding affinities

Our lab collaborates closely with investigators from other A*STAR research institutes, universities, and industry.

Research in the MSB lab is directed by Prof. Stephen Quake under an A*STAR Visting Investigatorship Programme grant, and by the lab's co-principal investigators, Dr. William F. Burkholder (IMCB) and Prof. Yin Thai Chan (IMRE and NUS).

All enquiries may be directed to Dr. William Burkholder and Dr. Yin Thai Chan.