Kam Man HUI
                       
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  Publications  
 

A blood-based three-gene signature for the non-invasive detection of early human hepatocellular carcinoma. 
Shi M, Chen MS, Sekar K, Tan CK, Ooi LL, Hui KM.
Eur J Cancer. 2014. In Press.

Isolation and elution of Hep3B circulating tumor cells using a dual-functional herringbone chip. 
Peng Xue, Kai Ye, Jie Gao, Yafeng Wu, Jinhong Guo, Kam M. Hui, Yuejun Kang. (Joint corresponding authors). 
Microfluidics and Nanofluidics; 2014 (in press).

A paper-based microfluidic electrochemical immunodevice integrated with amplification-by-polymerization for the ultrasensitive multiplexed detection of cancer biomarkers. 
Yafeng Wu, Peng Xue, Kam M Hui, Yuejun Kang. (Joint corresponding authors). 
Biosensors and Bioelectronics. 2014; 52:180-7.

Paper-based microfluidic electrochemical immunodevice integrated with nanobioprobes onto graphene film for ultrasensitive multiplexed detection of cancer biomarkers. 
Wu Y, Peng X, Kang Y, Hui KM. 
Anal Chem. 2013; 85(18):8661-8.

Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth. 
Ong HT, Federspiel MJ, Guo CM, Ooi LL, Russell SJ, Peng KW, Hui KM. 
Ann Oncol. 2013 59(5):999-1006.

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.  Subramaniam A, Shanmugam MK, Perumal E, Li F, Nachiyappan A, Dai X, Swamy SN, Ahn KS, Kumar AP, Tan BK, Hui KM, Sethi G.  (Joint corresponding authors) 
Biochim Biophys Acta- Reviews on Cancer. 2013; 1835(1):46-60.

Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model. 
Sia KC, Huynh H, Chung AY, Ooi LL, Lim KH, Hui KM, Lam PY. 
Mol Cancer Ther. 2013; 12(8):1651-64.

Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma.  Yulyana Y, Endaya BB, Ng WH, Guo CM, Hui KM, Lam PY, Ho IA. 
Stem Cells Dev. 2013; 22(13):1870-82.

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins. 
Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G. 
Apoptosis. 2013; 18(10): 1175-87.

Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis. 
Ho IA, Toh HC, Ng WH, Teo YL, Guo CM, Hui KM, Lam
PY.  Stem Cells. 2013; 31(1): 146-55.

The innovative evolution of cancer gene and cellular therapies. 
Lam P, Khan G, Stripecke R, Hui KM, Kasahara N, Peng KW, Guinn BA. 
Cancer Gene Ther. 2013; 20(3):141-9.

The deactivation of signal transducer and activator of transcription-3 activation signaling by emodin inhibits growth and induces apoptosis in orthotopic hepatocellular carcinoma model.  Subramaniam A, Shanmugam MK, Ong TH, Li F, Perumal E, Chen L, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Hui KM, Sethi G.  (Joint corresponding authors) 
Br J Pharmacol. 2013; 170(4):807-21.

Comprehensive detection of cancer gene expression profiles and gene networks are impacted by the choice of pre-processing algorithm and gene-selection method. 
Baskaran N, Kwoh CK, Hui KM. 
Int J Data Min Bioinform. 2013;7(4):416-35.

Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma. 
Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.  (Joint corresponding authors) 
PLoS One. 2013;8(3):e57015.

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. 
Xia H, Ooi LL, Hui KM. 
Hepatology. 2013; 58(2):629-41.

Highly specific and ultrasensitive graphene-enhanced electrochemical detection of low-abundance tumor cells using silica nanoparticles coated with antibody-conjugated quantum dots. 
Wu Y, Xue P, Kang Y, Hui KM. 
Anal Chem. 2013; 85(6):3166-73.

MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. 
Xia H, Ooi LL, Hui KM. 
PLoS One. 2012;7(9):e44206.

Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. 
Shanmugam MK, Ong TH, Kumar AP, Lun CK, Ho PC, Wong PT, Hui KM, Sethi G.  (Joint corresponding authors)
PLoS One. 2012;7(3):e32476.

Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging. 
Sia KC, Huynh H, Chinnasamy N, Hui KM, Lam PY. 
Gene Ther. 2012; 19(5): 532-42.

Gefitinib, cisplatin, and concurrent radiotherapy for locally advanced head and neck cancer: EGFR FISH, protein expression, and mutational status are not predictive biomarkers. 
Tan EH, Goh C, Lim WT, Soo KC, Khoo ML, Tan T, Tan DS, Ang MK, Ng QS, Tan PH, Lim A, Hwang J, Teng YH, Lim TH, Tan SH, Baskaran N, Hui KM.  Ann
Oncol. 2012; 23(4): 1010-6.

MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics.  Xia H, Hui KM. 
Cancer Gene Ther. 2012; 19(11): 723-30.

CIK cells--current status, clinical perspectives and future prospects--the good news. 
Hui KM. 
Expert Opin Biol Ther. 2012; 12(6): 659-61.

Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. 
Wang SM, Ooi LL, Hui KM. 
Clin Cancer Res. 2011; 17(18): 6040-51.

The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target.  Ong HT, Tan PK, Wang SM, Hian Low DT, Ooi LL, Hui KM. 
Cancer Gene Ther.  2011; 18(6): 399-406.

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. 
Shanmugam MK, Manu KA, Ong TH, Ramachandran L, Surana R, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. 
Int J Cancer. 2011; 129(7): 1552-63.

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. 
Shanmugam MK, Rajendran P, Li F, Nema T, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Ho PC, Hui KM, Sethi G. 
J Mol Med (Berl). 2011 Jul;89(7):713-27.

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.
Rajendran P, Ong TH, Chen L, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Hui KM, Sethi G. (Joint corresponding authors)   
Clin Cancer Res. 2011; 17(6): 1425-39.

Transcriptional down-regulation of IGFBP-3 in human hepatocellular carcinoma cells is mediated by the binding of TIA-1 to its AT-rich element in the 3'-untranslated region.  Subramaniam K, Ooi LL, Hui KM. 
Cancer Lett. 2010; 297(2): 259-68.

Cytokine-induced NK-like T cells: from bench to bedside. 
Linn YC, Hui KM. 
J Biomed Biotechnol. 2010;2010:435745.

Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. 
Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. 
J Pharmacol Exp Ther. 2010; 334(1): 285-93.

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. 
Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G. 
Cancer Lett. 2010; 292(2): 197-207.

Isolation of peptide ligands that interact specifically with human glioma cells. 
Ho IA, Hui KM, Lam PY.
Peptides. 2010; 31(4): 644-50.

Targeting human glioma cells using HSV-1 amplicon peptide display vector. 
Ho IA, Miao L, Sia KC, Wang GY, Hui KM, Lam PY. 
Gene Ther. 2010; 17(2): 250-60.

Modulation of iron-regulatory genes in human hepatocellular carcinoma and its physiological consequences. 
Tan MG, Kumarasinghe MP, Wang SM, Ooi LL, Aw SE, Hui KM. 
Exp Biol Med (Maywood). 2009; 234(6): 693-702.

Phenotypic and functional alterations of Vgamma2Vdelta2 T cell subsets in patients with active nasopharyngeal carcinoma. 
Puan KJ, Low JS, Tan TW, Wee JT, Tan EH, Fong KW, Chua ET, Jin C, Giner JL, Morita CT, Goh CH, Hui KM. 
Cancer Immunol Immunother. 2009; 58(7): 1095-107.

Matrix metalloproteinase 1 is necessary for the migration of human bone marrow-derived mesenchymal stem cells toward human glioma. 
Ho IA, Chan KY, Ng WH, Guo CM, Hui KM, Cheang P, Lam PY. 
Stem Cells. 2009; 27(6): 1366-75.

Human hepatocellular carcinoma: expression profiles-based molecular interpretations and clinical applications.
Hui KM. 
Cancer Lett. 2009; 286(1): 96-102.

 

 
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