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  Principal Investigators   IMCB JUNIOR Investigators   IMCB Independent Fellow   research fellows   research/Lab Officers   OTHER Opportunities    
     
 


Position of the Joint IMB-IMCB Electron Microscopy Suite Manager

Date available: Immediate

Date posted: 15, May 2015

The Joint IMB-IMCB Electron Microscopy Suite is a core technology platform of the Institute of Medical Biology (IMB) and the Institute of Molecular and Cell Biology (IMCB) of the Agency for Science Technology and Research (A*STAR) of Singapore. The mission of the suite is to provide electron microscopy imaging and image analysis tools with expertise to facilitate research in molecular, structural, cell and developmental biology. The 2 research institutes focus on different aspects of basic and biomedical translational science, using different models organisms ranging from flies, zebrafish and mice, as well as human biology. The Joint IMB-IMCB Electron Microscopy Suite is as impressive imaging facility with 4 electron microscopes (2 SEM and 2 TEM) and with a whole range of sample preparation equipment that includes a high pressure freezing system, automatic freeze substitution system, plunge freezer, ultra-microtomes, cryo ultratome-microtome, critical point drying device, glow discharge device, Gatan model 655 turbo pumping station etc. Further information about this facility can be found at:

https://www.a-star.edu.sg/imb/Tech-Platforms/IMB-IMCB-Joint-Electron-Microscopy-Suite/Equipment.aspx

Description:
We are looking for a motivated scientist who will support a fast-paced and exciting program in the Joint IMB-IMCB Electron Microscopy Suite, to lead, organize and further expand our EM operations. The successful candidate will be involved in different aspects of the operation of the IMB-IMCB Electron Microscopy Suite. This will include provision of a managerial role to all operations of the EM facility, service to researchers with their research projects involving EM techniques, as well as administrative duty. The candidate will also help and train users to implement EM procedures in their research.

The successful candidate must have:

  • a Ph.D. or/and M.D in a relevant discipline
  • strong experience with EM procedures (conventional SEM and TEM as well as EM-tomography, immune-EM, CLEM, cryo-TEM etc)
  • excellent research track record as evidenced by publications in international journals and strong training skills
  • experience in hands-on running of EM equipment
  • leadership qualities

We offer:

  • a challenging position and competitive remuneration package
  • access to state-of-the-art EM equipment
  • a stimulating, world-class and diverse international research environment

How to apply:

  • please describe you research interests in the motivation letter
  • CV with list of publications
  • a one page EM core facility implementation plan that describes how you would run the facility
  • the contact details of 2 references

Interested applicants are welcome to email all documents and contact numbers by to sudiptor@imcb.a-star.edu.sg  or recruit@imcb.a-star.edu.sg.

We regret that only shortlisted candidates will be contacted.



Research Fellow (Postdoctoral) Position

Date available: Immediate

Date posted: 10 April 2015

One research fellow (postdoctoral) position is immediately available in the Humanized mouse unit (HMU) of Institute of Molecular and Cell Biology, ASTAR, Singapore.

The understanding of many biological processes in humans has been relying on the experimental studies in animal models, particularly rodents. However, many aspects of human biological system are species specific, such as human specific cell types and immune genes. Moreover, many infectious organisms only infect human but no other animal species, and a lot of the new therapeutics and immunomodulatory reagents are human specific. Our mission is to develop humanized mouse models which closely recapitulate in vivo human biology for the study of human diseases and drug development, which is critical to understand and develop therapeutics to many human specific diseases. Research overview (Website: http://www.imcb.a-star.edu.sg/php/ittd-hmu.php)

Qualification/Requirements:

  • Undertake independent research under the direction of the PI and with other lab members.
  • Assist the PI in quality control for experiments, data analysis, manuscript preparation, grant applications and lab managementmetabolism.
  • Assist the PI in guiding and training students and junior research staff.
  • Present research achievements at internal and external seminars and conferences.

Please email a detailed CV containing a list of publications to
Dr. Qingfeng Chen, qchen@imcb.a-star.edu.sg
Or IMCB HR  recruit@imcb.a-star.edu.sg


We regret that only shortlisted candidates will be notified.

 


Research Fellow Position

Date available: Immediate

Date posted: 20 March 2015

A postdoctoral position is available in the laboratory of Dr. Vinay Tergaonkar at the Institute of Molecular and Cell Biology (IMCB), Singapore.
Reference: http://www.imcb.a-star.edu.sg/php/vinayt.php

Requirements:

  • Ph.D in Molecular biology, genetics, metabolism or related fields
  • One first author publication in a reputed international journal along with enthusiasm and active interest in pursuing research in area of genomics, cancer, inflammation and metabolism.
  • Experience in molecular biology, computational genomics (including next-generation sequencing analysis) and mouse genetics will be a plus.
Interested candidates are to email a detailed CV that includes research motivation and publication list to vinayt@imcb.a-star.edu.sg or recruit@imcb.a-star.edu.sg

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice.

We regret that only shortlisted candidates will be notified.


Postdoctoral Fellow Positions in
Translational Proteomics

Date available: Immediate

Date posted: 4 March 2015

Two research fellow positions in the Institute of Molecular and Cell Biology Quantitative Proteomics Group are immediately available for highly motivated candidates. The successful candidates will work on protein biomarker discovery and interactome biology projects.

Requirements:
Candidates with a Ph.D in Biochemistry/Bioscience or related area are invited to apply. Prior postdoctoral training in the field of using mass spectrometry-based proteomics, genomics and systems biology is preferred. Experience in molecular/cell biology and familiarity with downstream bioinformatics processing will be a plus. The successful candidates should be capable of executing independent research and also perform well in a team. Salary and benefits will be commensurable to educational qualifications, track record and working experience. Interested applicants should email his/her curriculum vitae, brief statement of research summary/prior experience and contact information of at least two references to recruit@imcb.a-star.edu.sg

We regret that only shortlisted candidates will be contacted.





Research Fellow Position

Date available: Immediate

Date posted: 2 March 2015

A position for Research Fellow/Officer is available in the laboratory of Dr. Chengqi LIN at the Institute of Molecular and Cell Biology (IMCB), Singapore.
Reference: http://www.imcb.a-star.edu.sg/php/iji-cl.php

Reponsibilities will include analyzing Next Generation Sequencing data including ChIP-seq, RNA-seq, Net-seq, miRNA-seq et al; optimising experimental designs, result discussion, final manuscript preparation and coordinating collaborations with research groups.

Requirements:

  • Master or PhD Degree in Bioinformatics, Molecular biology, Computer Science, or related fields;
  • Background in scripting languages, Python, C++, Java, R, Perl, or other related programming knowledge;
  • Experience in a computational or molecular biology lab (e.g. next-generation sequencing analysis);
  • Ability to work in a team and communicate effectively with biologists
  • Good publication records in peer-reviewed journals.
Interested candidates are to email a detailed CV that includes publications to cqlin@imcb.a-star..edu.sg or recruit@imcb.a-star.edu.sg

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice.





Positions in Next-Generation sequencing @ IMCB

Date available: Immediate

Date posted: 26 August 2014

Description:

The Institute of Molecular and Cell Biology (IMCB) is currently looking for a Research Scientist/ Fellow/ Officer (Next-Generation sequencing/wet lab) and a Research Fellow/ Officer (Bioinformatician).

1. Research Scientist/ Fellow/ Officer (Next-Generation sequencing/wet lab)

The successful candidate will play an essential role in research and development within IMCB, interacting with multiple scientists, and enabling the use of the NGS platform. He/She will be part of a highly motivated team of scientists and technicians, but is expected to work independently.

Responsibilities will include the preparation, development and optimization of genome- and transcriptome-sequencing (Next-Generation sequencing) libraries and protocols; managing and coordinating collaborations with research groups, participating in experimental design and contributing to final written reports.

Requirements:

  • Master or PhD degree in Biomedical Sciences.
  • Five years or more work experience in a molecular biology lab.
  • Experience with next-gen sequencing is preferred.
  • Familiarity with DNA sequencing, Primer-design softwares.

2. Research Fellow/ Officer (Bioinformatician)

The successful candidate will work in a dynamic multi-disciplinary team and collaborate with other bioinformaticians and biologists in supporting NGS research projects.

Responsibilities will include running pipelines for extracting and analyzing massive parallel sequencing data from Next Generation Sequencers; curate and integrating in-house genomic (ChIP-seq, DNA-seq, exon-seq, RNA-seq et al.) data sets.

Requirements:

  • Master or PhD Degree in Bioinformatics, Computer Science, or related disciplines.
  • Work experience in a computational or molecular biology lab.
  • Background in scripting languages, Perl/python, SQL, and Unix programming is essential.
  • Good working knowledge and experience in data management for genomic (ChIP-seq, DNA-seq, RNA-seq et al.) will be an advantage.

Interested applicants should send a CV and a brief description of research experience to:
Dr. Ernesto 
GUCCIONE
eguccione@imcb.a-star.edu.sg

or to
Human Resources Department, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Level 2, #02-02, Proteos Building, Singapore 138673; Fax: 6779 1117 or email to :
recruit@imcb.a-star.edu.sg

We regret that only shortlisted applicants will be notified.



Postdoctoral fellow position

Date available: Immediate

Date posted: 24 July 2014

The Institute of Molecular and Cell Biology (IMCB) is a leading research institute in biological sciences funded by the Agency for Science, Technology and Research (A*STAR). Its vision is to be a premier molecular biology and cell institute with increasing focus on addressing the mechanistic basis of human diseases. IMCB’s research activities focus on the areas of Animal Models of Development and Disease, Cancer Genetics and Therapeutics, Cell Biology in Health and Disease, and Structural Biology and Drug Discovery. IMCB is continuously looking out for talented people to contribute to its success.

Research Fellow

A postdoctoral research fellow position is immediately available for the PRL-3 Phosphatase & Cancer lab at IMCB. The successful applicant will be involved in an A*STAR project and is required to work closely with fellow team members from Dr Zeng’s laboratory. 

The successful candidate must be stimulated by interdisciplinary discussions and be motivated to develop and carry out strategies that assess outcomes of specific mission-oriented research.

Requirements:

  • PhD (or MD-PhD preferred) in Biology.
  • Self-motivated, with experience in animal cancer models and histology.
  • Demonstrated research experience in protein work, molecular cloning and cell culture.
  • Strong publication record in peer-reviewed journals.
  • Ability to work in a team and conduct independent research with excellent analytical, technical and problem solving skills.
  • Ability to present research progress at internal and external seminars/conferences.

Interested candidates are to email a detailed CV that includes research motivation and publication list to: Human Resources Department, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Level 2, #02-02, Proteos Building, Singapore 138673; Fax: 6779 1117 or email to : recruit@imcb.a-star.edu.sg or mcbzengq@imcb.a-star.edu.sg

We regret that only shortlisted applicants will be notified.





Postdoctoral research fellow position

Date available: Immediate

Date posted: 3 June, 2014

A Postdoctoral research fellow position is available immediately at the IMCB Epigenetics and Cell fates Laboratory. The laboratory is interested in developing novel tools and strategies in deriving differentiated cell types via defined factors reprogramming.

Applicants with relevant background in Stem cell biology, Haematology, Neurobiolgy or related fields are invited to apply. Experience with Human ESCs differentiation and mouse work would be highly desirable. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

  • Ph.D. from a well-recognized institution in Stem cell biology/Life Sciences/Biomedical Sciences
  • Strong publication record in peer-reviewed journals
  • Committed and able to work flexible hours
  • Ability to conduct high-quality independent research with excellent analytical, technical and problem solving skills.
  • Excellent communication, technical writing and presentation skills

Interested candidates are asked to send a cover letter detailing research motivations, CV, and the names and email addresses of three references to Jonathan Loh (yhloh@imcb.a-star.edu.sg). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

We regret that only shortlisted applicants will be notified.

References:

  1. Gore A et al. Somatic coding mutations in human induced pluripotent stem cells. (2011)
    Nature 471, 63-67.
  2. Agarwal S et al. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. (2010) Nature 464, 292-296.
  3. Loh YH et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. (2006) Nature Genetics 38, 431–440.





Postdoctoral Research Fellow Position

Date available: Immediate

Date posted: 5 May, 2014

The Institute of Molecular and Cell Biology (IMCB) is a leading research institute in biological sciences funded by the Agency for Science, Technology and Research (A*STAR). Its mission is to develop and foster a vibrant research culture for cutting-edge basic biomedical sciences. IMCB’s research activities focus on four major fields: Animal Models of Development and Disease, Cancer Genetics and Therapeutics, Cell Biology in Health and Disease, and Structural Biology and Drug Discovery. IMCB is continuously looking out for talented people.

The Monoclonal Antibody Unit (MAU) in IMCB aims to generate and characterize monoclonal antibodies that are useful for translational research.  We are also involved in virus research. We are now inviting suitable candidates to apply for the following position as part of a Joint Council Office Development Programme entitled “Establishment of a humanized mouse model for study of bona fide hepatitis virus infection, immune responses and drug development”.

Research Fellow

Responsibilities:

  • Contribute actively to the above programme by taking charge of the virology aspects including studying the infection of hepatitis B and C viruses in the humanized mouse model.

  • Perform molecular biology and biochemistry experiments such as cell culture, cloning, protein expression and purification, Western blot and immunofluorescence analyses.

  • Generation and characterization of monoclonal antibodies for therapeutic and diagnostic applications.

Requirements:

  • Prospective candidates should possess a Ph.D. in relevant fields such as virology or immunology.
  • Experience with animal handling, protein expression, microscopy imaging and immunological techniques is preferred.
  • Possess excellent academic records and technical skills, strong publication record in reputable international journals.
  • • A team player with good communication skills.

IInterested applicants are welcome to fax or write in with a detailed resume, supporting documents and contact numbers by to: Human Resources Department, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Level 2, #02-02, Proteos Building, Singapore 138673; Fax: 6779 1117 or email to : recruit@imcb.a-star.edu.sg

We regret that only shortlisted applicants will be notified.


Postdoctoral Research Fellow Position

Date available: Immediate

Date posted: 8 April, 2014

A postdoctoral research fellow position is immediately available at the Zebrafish Translational Unit in IMCB. The successful applicant will be involved in an A*STAR JCO funded project and is required to work closely with fellow team members from IMRE. 
The ideal candidate should hold a Ph.D. in molecular biology, developmental biology, biochemistry or other relevant fields. Experience in working with zebrafish, developing disease models and bioimaging is desired. The successful candidate must be stimulated by interdisciplinary discussions and be motivated to develop and carry out strategies that assess outcomes of specific mission oriented research.

Examples of published research conducted by the Zebrafish Translational Unit in IMCB highlighting the varied approaches used to validate performance of novel fabricated nanomaterials are listed in references below.

References:

  1. You WH, Teh C, Tan H, Wong S-Y, Zhang Y, Korzh V, Li X, Wang J: PEO surface-decorated silica nanocapsules and their application in in vivo imaging of zebrafish RSC Adv 2012(2):12392-12399.
  2. Yan H, Teh C, Sreejith S, Zhu L, Kwok A, Fang W, Ma X, Nguyen KT, Korzh V, Zhao Y: Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery in vivo. Angew Chem Int Ed Engl 2012, 51(33):8373-8377.
  3. Ma X, Teh C, Zhang Q, Borah P, Choong C, Korzh V, Zhao Y: Redox-Responsive Mesoporous Silica Nanoparticles: A Physiologically Sensitive Codelivery Vehicle for siRNA and Doxorubicin. Antioxid Redox Signal 2013.

Requirements:

  • Ph.D. from a well-recognized institution in Life Sciences/Biomedical Sciences.
  • Strong publication record in peer-reviewed journals.
  • The ability to work in a team and conduct independent research with excellent analytical, technical and problem solving skills.
  • Ability to present research progress at internal and external seminars/conferences.

Interested candidates are to email a detailed CV that includes research motivations, publication list and email address of at least 3 referees to Cathleen Teh (cathleen@imcb.a-star.edu.sg).

We regret that only shortlisted applicants will be notified.