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  Principal Investigators   IMCB JUNIOR Investigators   research fellows   research/Lab Officers   OTHER Opportunities    
     
 


Research Fellow Position in the Laboratory of Medical Structural Biology

Date available: immediately

Date posted: 22 March 2017


We are seeking an enthusiastic and self-motivated postdoctoral research fellow to work on structural and functional analysis of proteins involved in RNA metabolism and the Hippo signalling pathway. The applicants should have a background in structural biology, biophysics, biochemistry or a related field with a strong publication record. Candidates with experiences in structure determination by cryo-electron microscopy or in protein expression using insect/mammalian cells are preferred. Please send CV, including the names and addresses of three references to:

Prof.  Haiwei Song
Institute of Molecular and Cell Biology
61 Biopolis Drive
Proteos
Singapore 138673
Email:haiwei@imcb.a-star.edu.sg




Epigenetics Research Fellow in the Laboratory of Cancer Epigenome

Date available: immediate

Date posted: 24 February 2017

The Laboratory of Cancer Epigenome is interested in exploring how genetic and epigenetic aberrations drive tumorigenesis. We profile clinical samples to understand disease mechanisms, identify cancer vulnerabilities and develop novel therapeutic interventions. We are seeking for a creative, independent and motivated individual to join our team of cancer biologists, bioinformatics and clinician scientists.

Responsibilities:
*       Lead collaborative projects to elucidate epigenetic abnormality in cancer
*       Perform whole-genome profiling studies including ChIP-seq and RNAseq
*       Perform mechanistic studies to understand transcriptional regulation and tumorigenesis

Requirements:
*       Ph.D. in genetics, molecular biology, cancer biology or related field
*       Previous experience with next generation sequencing is preferred

Interested applicants please e-mail Prof. Teh Bin Tean at teh.bin.tean@singhealth.com.sg with CV and names/contact information of three references.




Biochemistry Research Fellow in the Laboratory of Cancer Epigenome

Date available: immediate

Date posted: 24 February 2017


The Laboratory of Cancer Epigenome is interested in exploring how genetic and epigenetic aberrations drive tumorigenesis. We profile clinical samples to understand disease mechanisms, identify cancer vulnerabilities and develop novel therapeutic interventions. We are seeking for a creative, independent and motivated individual to join our team of cancer biologists, bioinformatics and clinician scientists.

Responsibilities:
*      Lead collaborative projects to elucidate how genetic and epigenetic changes affect cell         metabolism in cancer
*      Perform biochemical studies including quantification of metabolites using mass spectrometry,         isotope tracing and other assays
*      Perform mechanistic studies to understand interplay between genetics, metabolism and         tumorigenesis

Requirements:
*       Ph.D. in biochemistry or related field
*       Previous experience with cancer metabolism is preferred
Interested applicants please e-mail Prof. Teh Bin Tean at teh.bin.tean@singhealth.com.sg with CV and names/contact information of three references.




Opening for a Post-Doctoral Researcher –
Training in Mechanobiology and Cancer Signaling at the Center of Research Excellence in Mechanobiology in Singapore

Date available: immediate

Date posted: 17 February 2017


A post-doctoral position is available within the National University of Singapore (NUS) for 3 years with a generous salary and benefits, starting immediately. We search for a highly motivated candidate who has a strong background in the analysis of gene transcription by CHIP assays and epigenetic signatures. An experience with the analysis and micro and/or long non-coding RNAs would be appreciated as well.  The main focus of the grant-funded project is to characterize genes that are regulated by YAP and TAZ transcriptional co-factors.

Please send a short cover letter stating research experience and interests, curriculum vitae, and the names and addresses of 3 references to Marius Sudol, Ph.D. (email: mbims@nus.edu.sg).




Research Fellow in the Laboratory of Molecular and Vascular Medicine

Date available: immediate

Date posted: 23 January 2017


Postdoctoral positions are available at the Laboratory of Molecular and Vascular Medicine. Our lab is interested to study how blood vessel dysfunctions underlie neurological diseases such as stroke and vascular dementia. We aim to advance the understanding of cerebrovascular complications through mechanistic interrogation of clinical biomarkers and development of human induced pluripotent stem cell-based disease models. Successful candidates must be highly motivated and be able to work in an interdisciplinary environment. For a research overview, please refer to http://www.imcb.a-star.edu.sg/php/iif-cc.php.

Responsibilities:

  • Initiate and lead projects related to mechanisms in neurovascular pathology.
  • Involve in experimental planning, data analysis, manuscript preparation and grant applications.
  • Present research findings at seminars and conferences.
  • Contribute to collaborative projects.
  • Guide and train students and junior lab members.
  • Assist in lab management with other lab members.
  • Uphold research integrity and ensure safety compliance.

Skills and qualifications:

  • Applicants should possess a PhD in life sciences, biomedical sciences, biochemistry, bioengineering or equivalent from a well-recognized university.
  • Experience with stem cells, molecular and cell biology, gene editing and/or bioinformaticswill be considered favorably.
  • Good publication records in peer-reviewed journals.
  • Able to undertake independent research and be an effective team player.
  • Strong analytical, technical and problem solving skills.
  • Committed, able to work flexible hours and within the deadline.
  • Excellent written and oral communication skills.

Application Procedure:

Please apply to Dr Christine Cheung (ccheung@imcb.a-star.edu.sg) with your CV, a cover letter of your research motivations, and contact details of at least 2 referees. Only shortlisted candidates will be notified.



Research Fellow

Date available: immediate

Date posted: 13 January 2017


Responsibilities:

The lab for microRNA Models of Neurodegenerative Disease at the Institute of Molecular and Cell Biology is seeking to recruit a highly motivated Research Fellow to investigate pathogenic pathways underlying neurodegeneration linked to loss of microRNA function.

The work will involve both in vitro and in vivo techniques, including cellular and molecular biology, generation and analysis of transgenic flies, behavioral assays, tissue dissections, immunohistochemical analysis and confocal microscopy.

Candidates must have a Ph.D. in Neuroscience, Cell Biology, Biochemistry, or a related discipline. The successful candidate will have expertise in genetics, advanced molecular biology techniques, a solid publication record, and strong scientific writing skills. They will be highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills, and the ability to work effectively in a team.

IMCB provides a competitive remuneration package commensurate with your specific qualifications and experience.  We welcome interested applicants to submit a brief cover letter, full CV and contact details of two professional referees to Dr Sherry Aw (syaw@imcb.a-star.edu.sg).

Applications will be accepted until the position is filled. We regret that only shortlisted applicants will be notified.

Job Requirements
Qualification & Field of Study
PhD in Neuroscience, Cell Biology, Biochemistry or other related field
Other Requirements (e.g. Skills, Competencies)

Genetics
Advanced Molecular Biology techniques
Confocal Microscopy
Microdissection




Research Fellow: Humanized Mouse Unit (HMU)

Date available: immediate

Date posted: 27 December 2016

One Research Fellow (postdoctoral) position is immediately available in the Humanized Mouse Unit (HMU) of the Institute of Molecular and Cell Biology, A*STAR, Singapore.

The understanding of many biological processes in humans relies on experimental studies in animal models, particularly rodents. However, many aspects of the human biological system are species specific, such as human specific cell types and immune genes. Our mission is to develop humanized mouse models which closely recapitulate in vivo human biology for the study of human diseases and drug development. This is critical to the understanding and development of therapeutics to many human specific diseases. For a research overview please refer to   http://www.imcb.a-star.edu.sg/php/ittd-hmu.php

Specific requirements:

  • The candidate should be self-driven to pursue a scientific career, motivated, independent and passionate about immunology research
  • Hold a PhD in a relevant field of immunology or virology.
  • Good knowledge and concept of immunology and demonstrated research experience and achievement
  • Good technical writing skills
  • Prior experience in working with mice, flow cytometry, immunofluorescence etc.

Responsibilities:

  • Undertake independent research under the direction of the PI and with other lab members
  • Assist the PI in quality control for experiments, data analysis, manuscript preparation, grant applications and lab management
  • Assist the PI in guiding and training students and junior research staff.
  • Present research achievements at internal and external seminars and conferences

Please email a detailed CV containing a list of publications to
Dr. Qingfeng Chen, qchen@imcb.a-star.edu.sg.

We regret that only shortlisted applicants will be notified.