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  Principal Investigators   IMCB JUNIOR Investigators   research fellows   research/Lab Officers   OTHER Opportunities    
     
 


CETSA NTU Research
Fellows (PhD)

Date available: immediate

Date posted: 5 Jan 2016

We are looking for talented Research Fellows (PhD) - (2 positions)

Workplace:  School of Biological Sciences, NTU @ One North
Form of employment: Full time, Project employment
Start date: ASAP

General description:

Our group is interested in application of thermally induced unfolding of proteins in drug target deconvolution. Thermal stability assays explore the observation that a purified protein in a specific state has a distinct unfolding behaviour and ligand engagement changes protein heat stability triggering melting shift.  We setup in School of Biological Sciences, NTU @ One North together with IMCB/A*STAR new mass spectrometry based cellular thermal shift assay (MS-CETSA) platform for drug discovery. With this approach biochemical changes due to e.g. drug treatment can be globally monitored to discover protein targets/off targets and novel biomarkers proteome wide. Such MS-CETSA experiments allow parallel biochemical profiling of a large number of proteins in cell lysates/whole cells as well as individual patient sample. The work is distributed into two teams; one working with cell biology, molecular biology techniques and the other focusing on quantitative mass spectrometry based proteomics.

Job description:

The cell biology team will be responsible for preparing experiments involving cell culture, Thermal Shift Assays for Mass spectrometry based drug/new compound screening. 
Mass spectrometry team is focused on method development, data analysis and communication with the collaborators.
Successful candidate will be leading projects from the start, deal with the data analysis and will communicate results to collaborators.

Research Fellow (1) qualifications.

  • You have a PhD within the field of biochemistry, molecular biology, biotechnology or equivalent
  • Hands on experience from laboratory work in the field of molecular biology, cell biology or protein chemistry is a requirement.
  • Mass spectrometry experience will be essential but not crucial
  • Programming skills i.e. R or Python are essential but not crucial
  • You are able to work in a structured mode and can adhere to stringent timelines
  • High-throughput work requires strict documentation and we expect you to have a thorough appreciation of the merits of GLP.

Research Fellow (2) qualifications.

  • You have a PhD within the field of biochemistry, molecular biology, biotechnology or equivalent.
  • Hands on experience from laboratory work in the field of molecular biology, cell biology or protein chemistry is a requirement.
  • Mass spectrometry experience is crucial
  • Programming skills i.e. R or Python are essential but not crucial
  • You are able to work in a structured mode and can adhere to stringent timelines.
  • High-throughput work requires strict documentation and we expect you to have a thorough appreciation of the merits of GLP.

Please send your resume, CV and contact details from 2 reference persons to the email address: CETSA_MS@ntu.edu.sg

Par Nordlund (NTU) / Radoslaw Sobota(IMCB)

We regret that only shortlisted applicants will be notified.




Immunology
Research Fellow (Postdoc) Position

Date available: immediate

Date posted: 27, October 2015

One research fellow (postdoctoral) position is immediately available in the Humanized mouse unit (HMU) of Institute of Molecular and Cell Biology, ASTAR, Singapore.

Our laboratory studies human infectious diseases and cancers using a combination of biochemical, molecular and immunological approaches in human-mouse chimera models. Our research is a fast-developing area in biomedical and bioengineering science, which is critical to understand and develop therapeutics to many human specific diseases. Research overview (Website: http://www.imcb.a-star.edu.sg/php/ittd-hmu.php)

Qualification/Requirement

  • The candidate should be self-driven to pursue a scientific career, motivated, independent and passionate about immunology research
  • Hold a doctoral degree or be in the final stage of completing doctoral study in a relevant field of immunology or virology.
  • Good knowledge and concept of immunology and demonstrated research experience and achievement
  • Good English proficiency and technical writing skill
  • Prior experience in working with mice, flow cytometry, immunofluorescence et al.

Responsibilities

  • Undertake independent research under the direction of the PI and with other lab members
  • Assist the PI in quality control for experiments, data analysis, manuscript preparation, grant applications and lab management
  • Assist the PI in guiding and training students and junior research staff.
  • Present research achievements at internal and external seminars and conferences

Please email a detailed CV containing a list of publications to
Dr. Qingfeng Chen, qchen@imcb.a-star.edu.sg or recruit@imcb.a-star.edu.sg



Bioinformatics Research Fellow (Postdoc) Position

Date available: 1, Dec 2015

Date posted: 9, October 2015

A bioinformatician postdoc position is available at the A*STAR IMCB – Laboratory of Chromatin Dynamics & Disease Epigenetics. The laboratory is interested to study how chromatin deficiencies underlie human diseases such as cancer and developmental disorders. We harness the power of Next-generation sequencing based methodologies to interrogate gene regulatory networks and chromatin organization in different cellular systems.

We are looking for exceptional candidates with computational biology background and experience to join our team. The candidate will be responsible for developing computational pipelines for integrative analyses of Next-generation sequencing data (generated in-house and/or published) including, but not limited to, ChIP-Seq, RNA-Seq, Chromosome-Conformation-Capture technologies etc. He/She will be an integral part of a highly dynamic and enthusiastic team focused on analyzing chromatin dynamics in disease and development.

Candidates with experience in analyzing genome-wide epigenetic data sets will be considered favorably.

Requirements:
    1. Masters or PhD Degree in Bioinformatics, Computer Science, or related fields;
    2. Proficiency in programming and scripting languages such as Perl, Python, C++, Java, R, or other related programming knowledge;
    3. Hands-on expertise with high-throughput 'omic' data, and skilled in the use of databases such as ENCODE, FANTOM, COSMIC and TCGA;
    4. Prior work experience in a computational or molecular biology lab;
    5. Publication records in peer-reviewed journals;
    6. trong communication skills and the ability to work as part of a team.

    Salary and benefits will be commensurable to educational qualifications, track record and working experience. Interested applicants should email his/her curriculum vitae, a cover letter addressing research interest, experience and skills, and contact information of three referees to
    Dr. Wee-Wei Tee
    (wwtee@imcb.a-star.edu.sg) or
    Human Resources Department (recruit@imcb.a-star.edu.sg).

    We regret that only shortlisted candidates will be notified.



Research Fellow (Postdoc) Position

Date available: 1, December 2015

Date posted: 29, September 2015

A research fellow/postdoc position is available at the A*STAR IMCB – Laboratory of Chromatin Dynamics & Disease Epigenetics. The laboratory is interested to study how chromatin deficiencies underlie human diseases such as cancer and developmental disorders. A comprehensive understanding of epigenetic-based mechanisms will allow us to: (1) elucidate disease mechanisms that will guide the development of new epigenetic-based therapeutic modalities, and (2) utilize this knowledge to re-engineer cellular phenotypes through manipulation of chromatin structure and function, for regenerative medicine applications.
We employ a varied experimental approach that includes the use of Next-Generation Sequencing technologies, genome-editing tools, biochemical and molecular assays, as well as stem cells and animal models to address our questions of interest.

We are looking for a highly motivated postdoc with relevant training in biochemistry, developmental biology, or related fields. Candidates with prior experience in genomics, neurodevelopment, or regenerative medicine will be considered favorably.

Specific requirements:

(1) Possess a Ph.D. in relevant field from a well-recognized University.
(2) Good publication records in peer-reviewed journals.
(3) Expertise in routine cell biology, biochemistry and molecular biology techniques
     (protein biochemistry, cloning, QPCR, etc).
(4) Highly motivated and passionate for research.
(5) Able to undertake independent research and be an effective team player.

Salary and benefits will be commensurable to educational qualifications, track record and working experience. Interested applicants should email his/her curriculum vitae, a cover letter addressing research interest, experience and skills, and contact information of three referees to
Dr. Wee-Wei Tee
(wwtee@imcb.a-star.edu.sg) or
Human Resources Department
(recruit@imcb.a-star.edu.sg).

We regret that only shortlisted candidates will be notified.



Postdoctoral research fellow position

Date available: Immediate

Date posted: 2, September 2015

A Postdoctoral research fellow position is available immediately at the IMCB Epigenetics and Cell fates Laboratory. The laboratory is interested in developing novel tools and strategies in deriving differentiated cell types via defined factors reprogramming.

Applicants with relevant background in Stem cell biology, Haematology, Neurobiolgy or related fields are invited to apply. Experience with Human ESCs differentiation and mouse work would be highly desirable. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

  • Ph.D. from a well-recognized institution in Stem cell biology/Life Sciences/Biomedical Sciences
  • Strong publication record in peer-reviewed journals
  • Committed and able to work flexible hours
  • Ability to conduct high-quality independent research with excellent analytical, technical and problem solving skills.
  • Excellent communication, technical writing and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh (yhloh@imcb.a-star.edu.sg). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:

  1. Yang BX et al.
    Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. (2015) Cell (In press)
  2. Yu L et al.
    Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. (2014)
    Cell Stem Cell 15(1), 92-101.
  3. Gore A et al.
    Somatic coding mutations in human induced pluripotent stem cells. (2011)
    Nature 471, 63-67.
  4. Agarwal S et al.
    Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. (2010)
    Nature
    464, 292-296.
  5. Loh YH et al.
    The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. (2006)
    Nature Genetics 38, 431–440.

We regret that only shortlisted candidates will be notified.



Research Fellow position

Date available: Immediate

Date posted: 19, August 2015

Research Fellow (post-doctoral) position is available at Singapore A*STAR IMCB’s Laboratory for Multiscale Molecular Diagnostics. Integrating advances in materials science, biomedical engineering and molecular biology, the laboratory aims to develop novel micro- and nanotechnologies to empower biomarker discovery and its clinical translation. Please visit our lab website to find out more (http://www.imcb.a-star.edu.sg/php/iif-hs.php)

Applicants with relevant background in Bioengineering, Electrical Engineering, Mechanical Engineering, Chemistry, Physics, Molecular Biology or related fields are invited to apply. Successful candidates must be interested in translational research, highly motivated, and be able to work in an interdisciplinary environment.

Requirements

  • PhD from a well-recognized institution.
  • Excellent analytical, technical and problem solving skills.
  • Excellent organizational skills.
  • Committed and motivated.
  • Experience in microfabrication, microfluidics, nanotechnology, sensor development, assay development or other relevant techniques are highly desirable.

Interested candidates should send a cover letter detailing your research motivations, CV, and the names and contact information of three references to Dr. Huilin SHAO (hshao@imcb.a-star.edu.sg).

Only shortlisted candidates will be notified.



Research Fellow position

Date available: Immediate

Date posted: 11, August 2015

The Institute of Molecular and Cell Biology (IMCB) is a leading research institute in biological sciences primarily funded by the Agency for Science, Technology and Research (A*STAR). Its mission is to develop and foster a vibrant research culture for cutting-edge basic biomedical sciences.

The laboratory of Neurotechnology is seeking a motivated and independent candidate that is able to design and carry out the experiments, analyze data, write papers and coordinate small groups of research assistants and engineers that help with the projects. Training will be provided for those candidates without prior experience in non-human primate experiments.

Projects available include:
-Neural dynamics in prefrontal cortex during Visual working memory. This ongoing project uses 256 chronically implanted microelectrodes across multiple prefrontal regions to explore inter-area interactions during task performance.
 
-Hippocampal processing during virtual and real world navigation. In this project, to begin in mid-2015, we will chronically implant 124 electrodes in the hippocampus of monkeys while they perform navigation tasks. 

-Somatosensory Cortical Brain-Machine Interface. In this project, to begin in mid-2015, we will chronically implant microelectrodes in primary somatosensory cortex to explore the large space of stimulation parameters (using a 64-channel microstimulator built in-house). The goal is to endow animals with somatosensory feedback from robotic arms.
 
-Motor Cortical Brain-Machine Interface. In this project, to begin in 2016, we will chronically implant recording microelectrodes in the primary motor and premotor cortices of monkeys. Activity will be decoded in real-time to control multiple robotic devices.
 
-Motor Peripheral Nerve Neuroprosthesis. This ongoing project uses in house-built electrodes to record from peripheral nerves with the goal of restoring motor function via functional electrical stimulation. 

-Sensory Peripheral Nerve Neuroprosthesis. In this project, to begin in mid-2015, we will use in house-built electrodes to stimulate from peripheral nerves with the goal of restoring touch sensation, as well as to control organ function (such as bladder or adrenal gland) using nerve microstimulation (electroceuticals).

Requirements
Must Have

  • A PhD in Neuroscience, Biology, Bioengineering or a related discipline
  • Programming experience in Matlab
  • Experience in cortical or nerve neurophysiology and/or microstimulation (depending on the project).

Good to have (but not essential)

  • Experience with non-human primate research
  • Experience with animal training
  • Experience with prefrontal, hippocampus, motor, somatosensory cortex or peripheral nerve research.

Please submit your application, a detailed CV (including personal particulars, academic and employment history, complete list of publications and full contacts of 3 referees) to: Camilo Libedinsky (camilo@nus.edu.sg).

We regret that only shortlisted candidates will be notified.