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  Principal Investigators   IMCB JUNIOR Investigators   research fellows   research/Lab Officers   OTHER Opportunities    
     
 


Research Fellow: Chromatin Dynamics & Disease Epigenetics’ Group

Date available: immediate

Date posted: 17 Aug 2016

An immediate postdoctoral position is available in the ‘Chromatin Dynamics & Disease Epigenetics’ group in IMCB, A*STAR. We are looking for a highly motivated postdoc with relevant training in biochemistry, genomics and stem cell research. Candidates with experience in human ESCs/iPSCs and neurobiology will be considered favorably. He/She willconduct research related to epigenetic regulation in stem cells and neurological diseases

Specific requirements:

  1. Possess a Ph.D. in relevant field from a well-recognized University.
  2. A good publication record in peer-reviewed journals.
  3. Expertise in biochemistry and molecular biology techniques.
  4. Experience in human ESCs/iPSCs and neural differentiation.
  5. Highly motivated and passionate for research.
  6. Able to undertake independent research and be an effective team player.

Job Responsibilities:
Initiate, conduct and lead project related to epigenetic regulation in stem cells and neurodevelopment

Job Requirements:
Initiate, conduct and lead project related to epigenetic regulation in stem cells and neurodevelopment

Interested candidates are to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Dr. Tee Wee Wei (wwtee@imcb.a-star.edu.sg).

We regret that only shortlisted applicants will be notified.




Central Imaging Facility Microscopy
(Research Officer / Scientist)

Date available: immediate

Date posted: 20 July 2016

The IMCB Central Imaging Facility (CIF) is an Infrastructure, Technology and Translational Division (ITTD) unit that supports the imaging and image analysis needs of IMCB.

The CIF is seeking suitably qualified candidates to apply for the position of
Central Imaging Facility Microscopy Research Officer or Scientist

Job description:

  1. Point of contact for advice and help on microscopes.
  2. Train, advise and support users in the application of various microscopy techniques to biomedical research: from basic microscopy (brightfield, contrast enhancing techniques, widefield fluorescence and confocal) to advanced microscopy (F-techniques, 3D imaging, live-cell imaging, super‐resolution microscopy) and quantitative image analysis.
  3. Troubleshoot, provide basic maintenance and upkeep of microscope systems.
  4. Manage booking system.
  5. Liaise with the manufacturers/vendors for repairs, upgrades, application support and new developments.
  6. Hold the N3 laser license for IMCB.
  7. Propose a budget for maintenance, repairs, replacement of existing equipment and new acquisitions, and manage the approved budget.
  8. Develop collaborative research projects with research staff on specific scientific projects.
  9. Work with CIF Imaging Informatics Research Scientist to advise IMCB researchers on image acquisition, data handling, image processing and analysis and data presentation.
  10. Monitor safe working conditions and implement measures as required.
  11. Join the Safety Committee.
  12. Perform other administrative duties.

Requirements:

  1. Possess at least a B.Sc. (for Research Officer) or Ph.D (for Research Scientist) in one of the Life Sciences.
  2. Have at least 3 years hands-on experience in confocal and light microscopy.
  3. Good understanding of the principles of microscopy.
  4. Possess excellent communication and organizational skills.
  5. Committed to exceeding quality standards and providing exceptional services.

nterested applicants are to apply through:

https://astar.aqayo.com/site-YXN0YXJ8MjA/member_offerdetail.jsp? siteid=YXN0YXJ8MjA&requisitionuid=fbfbf22f20fbaa405d51ca7ea44a815b19801eca

or

https://astar.aqayo.com/site-YXN0YXJ8MjA/member_offerdetail.jsp? siteid=YXN0YXJ8MjA&requisitionuid=f619ac26a1c53601a62e40a9f06c7ca89ce8f9e9



Research Fellow Position in Structural Biology

Date available: immediate

Date posted: 28 June 2016

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to work on structural and functional analysis of proteins involved in RNA metabolism and the Hippo signalling pathway. Candidates with an interest in the development of small molecules to target the Hippo pathway for cancer therapeutics are also welcome. Candidates must have experience in protein or nucleic acid structure determination by X-ray crystallography and demonstrated success in molecular biology and protein expression using insect or mammalian cells.  Excellent communication skills are essential.

Further information is available at: http://www.imcb.a-star.edu.sg/php/shw.php.  Applicants must have a PhD with a strong publication record. Please send CV, including the names and addresses of three references, to: Dr. Haiwei Song haiwei@imcb.a-star.edu.sg.

 

 



Postdoctoral
Fellow Position (2 positions)

Date available: immediate

Date posted: 12 April 2016

Nanyang Technological University is a leading university within life sciences both regionally and globally. The Institute of Molecular and Cell Biology (IMCB) is a top research institute in biological sciences funded by the Agency for Science, Technology and Research (A*STAR).
Both of these well renowned research organizations are continuously looking for talented people to contribute to their success.

NTU/IMCB Professor Pär Nordlund is now recruiting two (2) Postdocs to his CETSA team (see recommended publication).

The fundamental basics of the CETSA method is to monitor the thermostability of proteins in the cell and hence study drug target engagement, off-target effects and resistance, etc. The laboratory is located in the heart of Singapore at One North and is shared with a drug discovery team and a bioengineering team who are supported by a HTP protein production platform. It is well equipped with state-of-the-art instruments for protein chemistry and biophysics, crystallography and cell biology.

The successful applicants will join the growing CETSA team of ambitious scientists exploring the new breakthrough technology for monitoring drug actions in cells and tissues.

The applicants must have a PhD in a life science related field and be cell biologists with extensive experience working with drugs and chemical probes and many different cell lines including primary cells. Mass spectrometry experience will be looked favorably upon. Clear communication skills are essential.

Candidates are invited to send a full CV, including a publication list, together with contact information for two references to: Prof. Pär Nordlund (PNORDLUND@ntu.edu.sg) or Dr. Sue-Li Dahlroth (sdahlroth@ntu.edu.sg).

Only shortlisted candidates will be contacted.

Recommended publication:

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P. Science. 2013 Jul 5;341(6141):84-7. 

 



Research Fellow (PhD) - (1 position)

Date available: immediate

Date posted: 12 April 2016

Workplace:  School of Biological Sciences, NTU @ One North
Form of employment: Full time, Project employment
Start date: ASAP

General description
Our group is interested in application of thermally induced unfolding of proteins in drug target deconvolution. Thermal stability assays explore the observation that a purified protein in a specific state has a distinct unfolding behaviour and ligand engagement changes protein heat stability triggering melting shift.  We are at the School of Biological Sciences, NTU @ One North together with the new IMCB/A*STAR mass spectrometry based cellular thermal shift assay (MS-CETSA) platform for drug discovery. With this approach biochemical changes due to e.g. drug treatment can be globally monitored to discover protein targets/off targets and novel biomarkers proteome wide. Such MS-CETSA experiments allow parallel biochemical profiling of a large number of proteins in cell lysates/whole cells as well as individual patient sample. The work is distributed into two teams; one working with cell biology, molecular biology techniques and the other focusing on quantitative mass spectrometry based proteomics. 

Job description

We are now looking for a Research Fellow to work in the cell biology team.

The successful candidate will be responsible for project development as well as interactions with collaborators.

Qualifications:

  • You have a PhD within the field of biochemistry, molecular biology, cell biology, biotechnology or equivalent.
  • Hands on experience from laboratory work in the field of molecular biology, cell biology and/or protein chemistry is a requirement. 
  • Strong analytical and problem solving skills in combination with strategic thinking is a must
  • You are able to work in a structured mode and can adhere to stringent timelines.
  • High-throughput work requires strict documentation and we expect you to have a thorough appreciation of the merits of GLP.
  • You have excellent communication skills, both written and oral. 
  • Keen interest or experience with MS is a plus but not a requirement.

The successful candidate will join a team of ambitious research fellows and technicians at NTU @ One North.

Please send in your resume, CV, cover letter stating your reasons for applying for this position and contact details from 2 reference persons to the email address: CETSA_MS@ntu.edu.sg
Par Nordlund (NTU) / Radoslaw Sobota (IMCB)

Only shortlisted candidates will be called for interview.

References:
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P. Science. 2013 Jul 5;341(6141):84-7.



Postdoctoral
Research Fellow Position

Date available: immediate

Date posted: 7 March 2016

A Postdoctoral research fellow position is available immediately at the IMCB Epigenetics and Cell fates Laboratory. The laboratory is interested in developing novel tools and strategies in deriving differentiated cell types via defined factors reprogramming.

Applicants with relevant background in Stem cell biology, Haematology, Neurobiolgy or related fields are invited to apply. Experience with Human ESCs differentiation and mouse works would be highly desirable. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

  • Ph.D. from a well-recognized institution in Stem cell biology/Life Sciences/Biomedical Sciences
  • Strong publication record in peer-reviewed journals
  • Committed and able to work flexible hours
  • Ability to conduct high-quality independent research with excellent analytical, technical and problem solving skills.
  • Excellent communication, technical writing and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh (yhloh@imcb.a-star.edu.sg). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:
    1. Yang BX et al. Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. (2015) Cell 163(1):230-45
    2. Yu L et al. Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. (2014) Cell Stem Cell 15(1), 92-101.
    3. Gore A et al. Somatic coding mutations in human induced pluripotent stem cells. (2011)
      Nature 471, 63-67.
    4. Agarwal S et al. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. (2010) Nature 464, 292-296.
    5. Loh YH et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. (2006) Nature Genetics 38, 431–440.





Bioinformatician position


Date available: immediately

Date posted: 7 March, 2016

A Postdoctoral Bioinformatician position is available immediately at the IMCB Epigenetics and Cell fates Laboratory. The laboratory is interested in dissecting the genetic and epigenetic mechanisms regulating cell fate changes, while developing novel tools and strategies in deriving differentiated cell types via defined factors reprogramming. Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

  • Ph.D. from a well-recognized institution with a strong research background in Bioinformatics /Computer science/Biostatistics or equivalent
  • Experience in bioinformatics and data analysis for DNA microarray, ChIP-seq and RNA-seq
  • Experience with open source bioinformatics tools
  • Excellent analytical, technical and problem solving skills
  • Knowledge with biostatistics highly desirable
  • Self-starter who is comfortable working in a fast moving interdisciplinary team
  • Strong publication record in peer-reviewed journals
  • Committed and able to work flexible hours
  • Excellent communication, technical writing and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh (yhloh@imcb.a-star.edu.sg). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:
    1. Yang BX et al. Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. (2015) Cell 163(1):230-45
    2. Yu L et al. Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. (2014) Cell Stem Cell 15(1), 92-101.
    3. Gore A et al. Somatic coding mutations in human induced pluripotent stem cells. (2011)
      Nature 471, 63-67.
    4. Agarwal S et al. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. (2010) Nature 464, 292-296.
    5. Loh YH et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. (2006) Nature Genetics 38, 431–440.

     



Immunology
Research Fellow (Postdoc) Position

Date available: immediate

Date posted: 27, October 2015

One research fellow (postdoctoral) position is immediately available in the Humanized mouse unit (HMU) of Institute of Molecular and Cell Biology, ASTAR, Singapore.

Our laboratory studies human infectious diseases and cancers using a combination of biochemical, molecular and immunological approaches in human-mouse chimera models. Our research is a fast-developing area in biomedical and bioengineering science, which is critical to understand and develop therapeutics to many human specific diseases. Research overview (Website: http://www.imcb.a-star.edu.sg/php/ittd-hmu.php)

Qualification/Requirement

  • The candidate should be self-driven to pursue a scientific career, motivated, independent and passionate about immunology research
  • Hold a doctoral degree or be in the final stage of completing doctoral study in a relevant field of immunology or virology.
  • Good knowledge and concept of immunology and demonstrated research experience and achievement
  • Good English proficiency and technical writing skill
  • Prior experience in working with mice, flow cytometry, immunofluorescence et al.

Responsibilities

  • Undertake independent research under the direction of the PI and with other lab members
  • Assist the PI in quality control for experiments, data analysis, manuscript preparation, grant applications and lab management
  • Assist the PI in guiding and training students and junior research staff.
  • Present research achievements at internal and external seminars and conferences

Please email a detailed CV containing a list of publications to
Dr. Qingfeng Chen, qchen@imcb.a-star.edu.sg or recruit@imcb.a-star.edu.sg



Postdoctoral research fellow position

Date available: Immediate

Date posted: 2, September 2015

A Postdoctoral research fellow position is available immediately at the IMCB Epigenetics and Cell fates Laboratory. The laboratory is interested in developing novel tools and strategies in deriving differentiated cell types via defined factors reprogramming.

Applicants with relevant background in Stem cell biology, Haematology, Neurobiolgy or related fields are invited to apply. Experience with Human ESCs differentiation and mouse work would be highly desirable. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

  • Ph.D. from a well-recognized institution in Stem cell biology/Life Sciences/Biomedical Sciences
  • Strong publication record in peer-reviewed journals
  • Committed and able to work flexible hours
  • Ability to conduct high-quality independent research with excellent analytical, technical and problem solving skills.
  • Excellent communication, technical writing and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh (yhloh@imcb.a-star.edu.sg). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:

  1. Yang BX et al.
    Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. (2015) Cell (In press)
  2. Yu L et al.
    Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. (2014)
    Cell Stem Cell 15(1), 92-101.
  3. Gore A et al.
    Somatic coding mutations in human induced pluripotent stem cells. (2011)
    Nature 471, 63-67.
  4. Agarwal S et al.
    Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. (2010)
    Nature
    464, 292-296.
  5. Loh YH et al.
    The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. (2006)
    Nature Genetics 38, 431–440.

We regret that only shortlisted candidates will be notified.