Jonathan Yuin-Han LOH
                       
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Cheng H, Ang HY, A El Farran C, Li P, Fang HT, Liu TM, Kong SL, Chin ML, Ling WY, Lim EK, Li H, Huber T, Loh KM, Loh YH*, Lim B.
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nat Commun.
2016 Nov 21;7:13396.
*As Corresponding author

Khattar E, Kumar P, Liu CY, Akıncılar SC, Raju A, Lakshmanan M, Maury JJ, Qiang Y, Li S, Tan EY, Hui KM, Shi M, Loh YH, Tergaonkar V.
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression
 J Clin Invest. 2016 Sep 19. pii: 86042. doi: 10.1172/JCI86042. [Epub ahead of print]

Chen HY, Tan HK, Loh YH*.
Derivation of Transgene-Free Induced Pluripotent Stem Cells from a Single Drop of Blood. 
Curr Protoc Stem Cell Biol. 2016 Aug 17;38:4A.9.1-4A.9.10.
*As Corresponding author

Cheow LF, Courtois ET, Tan Y, Viswanathan R, Xing Q, Tan RZ, Tan DS, Robson P, Loh YH, Quake SR, Burkholder WF.
Single-cell multimodal profiling reveals cellular epigenetic heterogeneity. 
Nat Methods. 2016 Aug 15. doi: 10.1038/nmeth.3961. [Epub ahead of print]

Sivalingam J, Lam AT, Chen HY, Yang BX, Chen AK, Reuveny S, Loh YH, Oh SK.
Superior Red Blood Cell Generation from Human Pluripotent Stem Cells Through a Novel Microcarrier-Based Embryoid Body Platform
Tissue Eng Part C Methods.
 2016 Aug;22(8):765-80. doi: 10.1089/ten.TEC.2015.0579. Epub 2016 Aug 1.

Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ.
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. 
Cell Stem Cell. 2016 Jul 7;19(1):66-80. Epub 2016 Jun 16.

Toh CX, Chan JW, Chong ZS, Wang HF, Guo HC, Satapathy S, Ma D, Goh GY, Khattar E, Yang L, Tergaonkar V, Chang YT, Collins JJ, Daley GQ, Wee KB, Farran CA, Li H, Lim YP, Bard FA, Loh YH*.
RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming. 
Cell Rep. 2016 Jun 21;15(12):2597-607. Epub 2016 Jun 9.
*As Corresponding author

Zhang W, Ni P, Mou C, Zhang Y, Guo H, Zhao T, Loh YH*, Chen L.
Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. 
Sci Rep.
 2016 May 26;6:26804.
*As Corresponding author

Seah YF, El Farran CA, Warrier T, Xu J, Loh YH*.
Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges. 
Int J Mol Sci. 2015 Dec 2;16(12):28614-34.
*As Corresponding author

Yu S, Ma H, Ow JR, Goh Z, Chiang R, Yang H, Loh YH*, Wu Q.
Zfp553 Is Essential for Maintenance and Acquisition of Pluripotency. 
Stem Cells Dev. 2016 Jan 1;25(1):55-67. Epub 2015 Dec 15.
*As Corresponding author

Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, Loh YH*.
Systematic identification of factors for provirus silencing in embryonic stem cells.  
Cell. 2015 Sep 24;163(1):230-45. Epub 2015 Sep 10.
*As Corresponding author

Maury JJ, El Farran CA, Ng D, Loh YH, Bi X, Bardor M, Choo AB.
RING1B O-GlcNAcylation regulates gene targeting of polycomb repressive complex 1 in human embryonic stem cells.  
Stem Cell Res. 2015 Jul;15(1):182-9. Epub 2015 Jun 17.

Ma H, Ow JR, Tan BC, Goh Z, Feng B, Loh YH, Fedele M, Li H, Wu Q. The dosage of Patz1 modulates reprogramming process. 
Sci Rep. 2014 Dec 17;4:7519.

Faucon PC, Pardee K, Kumar RM, Li H, Loh YH, Wang X.
Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions.  
PLoS One. 2014 Jul 24;9(7):e102873.

Lu Y, Loh YH*, Li H, Cesana M, Ficarro SB, Parikh JR, Salomonis N, Toh CX, Andreadis ST, Luckey CJ, Collins JJ, Daley GQ, Marto JA.
Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells.  
Cell Stem Cell. 2014 Jul 3;15(1):92-101. Epub 2014 May 8.
*As Co-first author

Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH*.
Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking. 
Stem Cells Transl Med. 2014 May;3(5):586-98. Epub 2014 Mar 19.
*As Corresponding author

Ma H, Ng HM, Teh X, Li H, Lee YH, Chong YM, Loh YH, Collins JJ, Feng B, Yang H, Wu Q.
Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency.  
PLoS Genet. 2014 Feb 13;10(2):e1004038.

Wen B, Wu H, Loh YH*, Briem E, Daley GQ, Feinberg AP.
Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions.  
BMC Genomics. 2012 Oct 26;13:566.
*As Co-first author

Bajpai VK, Mistriotis P, Loh YH, Daley GQ, Andreadis ST.
Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.  
Cardiovasc Res. 2012 Dec 1;96(3):391-400. Epub 2012 Aug 31.

Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ.
Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. 
Curr Protoc Stem Cell Biol. 2012;Chapter 4:Unit4A.5.

De Los Angeles A, Loh YH, Tesar PJ, Daley GQ.
Accessing naïve human pluripotency. 
Curr Opin Genet Dev. 2012 Jun;22(3):272-82. Epub 2012 Mar 29.

Kim K, Zhao R, Doi A, Ng K, Unternaehrer J, Cahan P, Huo H, Loh YH, Aryee MJ, Lensch MW, Li H, Collins JJ, Feinberg AP, Daley GQ.
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.  
Nat Biotechnol. 2011 Nov 27;29(12):1117-9.

Ang WX, Toh CX, Ng HH, Loh YH*.
Reproductive medicine gets a new tool. 
J Mol Cell Biol. 2011 Dec;3(6):320-1. Epub 2011 Nov 24.
*Corresponding author

Brock A, Goh HT, Yang B, Lu Y, Li H, Loh YH*.
Cellular reprogramming: a new technology frontier in pharmaceutical research. 
Pharm Res. 2012 Jan;29(1):35-52. Epub 2011 Nov 9.
*As Corresponding author

Loh YH, Yang L, Yang JC, Li H, Collins JJ, Daley GQ.
Genomic approaches to deconstruct pluripotency. 
Annu Rev Genomics Hum Genet. 2011;12:165-85.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.
Somatic coding mutations in human induced pluripotent stem cells. 
Nature. 2011 Mar 3;471(7336):63-7.

Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. 
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.

Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ.
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. 
Cell Stem Cell. 2010 Nov 5;7(5):618-30. Epub 2010 Sep 30. *Co-second author.

Loh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, Irion S, Daley GQ.
Reprogramming of T cells from human peripheral blood.  
Cell Stem Cell
. 2010 Jul 2;7(1):15-9.

Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ.
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. 
Nature. 2010 Mar 11;464(7286):292-6. Epub 2010 Feb 17.

Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH.
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. 
Genes Dev. 2009 Nov 1;23(21):2507-20.

Chan EM, Ratanasirintrawoot S, Park IH, Manos PD, Loh YH, Huo H, Miller JD, Hartung O, Rho J, Ince TA, Daley GQ, Schlaeger TM.
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. 
Nat Biotechnol. 2009 Nov;27(11):1033-7. Epub 2009 Oct 11.

Loh YH, Agarwal S, Park IH, Urbach A, Huo H, Heffner GC, Kim K, Miller JD, Ng K, Daley GQ.
Generation of induced pluripotent stem cells from human blood. 
Blood. 2009 May 28;113(22):5476-9. Epub 2009 Mar 18.

Feng B, Jiang J, Kraus P, Ng JH, Heng JC, Chan YS, Yaw LP, Zhang W, Loh YH, Han J, Vega VB, Cacheux-Rataboul V, Lim B, Lufkin T, Ng HH.
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. 
Nat Cell Biol. 2009 Feb;11(2):197-203. Epub 2009 Jan 11.

Ng JH, Heng JC, Loh YH*, Ng HH.
Transcriptional and epigenetic regulations of embryonic stem cells. 
Mutat Res. 2008 Dec 1;647(1-2):52-8. doi: 10.1016/j.mrfmmm.2008.08.009. Epub 2008 Aug 20.
*As Corresponding author

Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH.
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. 
Cell. 2008 Jun 13;133(6):1106-17.

Loh YH*, Ng JH, Ng HH.
Molecular framework underlying pluripotency. 
Cell Cycle. 2008 Apr 1;7(7):885-91. Epub 2008 Jan 22.
*As Corresponding author

Jiang J, Chan YS, Loh YH*, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH.
A core Klf circuitry regulates self-renewal of embryonic stem cells. 
Nat Cell Biol. 2008 Mar;10(3):353-60. Epub 2008 Feb 10.
*As Co-second author

Loh YH, Zhang W, Chen X, George J, Ng HH.
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. 
Genes Dev. 2007 Oct 15;21(20):2545-57.

Lim LS, Loh YH*, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW.
Zic3 is required for maintenance of pluripotency in embryonic stem cells. 
Mol Biol Cell. 2007 Apr;18(4):1348-58. Epub 2007 Jan 31.
*Co-first author

Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH.
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. 
J Biol Chem. 2006 Aug 25;281(34):24090-4. Epub 2006 Jul 13.

Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao X.D, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH.
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. 
Nat Genet. 2006 Apr;38(4):431-40. Epub 2006 Mar 5.

Chew JL, Loh YH*, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH.
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Mol Cell Biol. 2005 Jul;25(14):6031-46.* Co-first author

Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH,
Robson P.
Transcriptional regulation of nanog by OCT4 and SOX2. 
J Biol Chem. 2005 Jul 1;280(26):24731-7. Epub 2005 Apr 27

 

 
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