Jonathan Yuin-Han LOH
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Cheow, L.F., Courtois, E.T., Tan, Y., Viswanathan, R., Xing, Q., Tan, R.Z., Tan, D.S., Robson, P., Loh Y.H., Quake, S.R., Burkholder, W.F. 2016.
Single-cell multimodal profiling reveals cellular epigenetic heterogeneity.
Nature Methods
. [Epub ahead of print]

CSivalingam J, Lam AT, Yu-Chen H, Xia-Yang B, Chen AK, Reuveny S, Loh YH, Oh SK.
Superior red blood cell generation from human pluripotent stem cells via a novel microcarrier based embryoid body platform.
Tissue Eng Part C Methods. 2016 Jul 8. [Epub ahead of print]

Chen, H.Y., Tan, H.K. & Loh, Y. H.* 2016.
Derivation of transgene-free induced pluripotent stem cell from a single drop of blood.
Current Protocol in Stem Cell Biology
, Chapter 38, Unit 4A.9.1-9.10.
*As Corresponding author

Toh, C. X., Chan, J. W., Chong, Z. S., Wang, H. F., Guo, H. C., Satapathy, S., Ma, D., Goh, G. Y., Khattar, E., Yang, L., Tergaonkar, V., Chang, Y. T., Collins, J. J., Daley, G. Q., Wee, K. B., Farran, C. A., Li, H., Lim, Y. P., Bard, F. A. & Loh, Y. H.* 2016.
RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming.
Cell Report, 15, 2597-607. [Epub 2016 Jun 9]
*As Corresponding author

Zhang, W., Ni, P., Mou, C., Zhang, Y., Guo, H., Zhao, T., Loh, Y. H.* & Chen, L. 2016.
Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription.
Science Report
, 6, 26804.
*As Co-corresponding author

Zhang, J., Ratanasirintrawoot, S., Chandraekaran, S., Wu, Z., Ficarro, S. B., Yu, C., Ross, C. A., Cacchiarelli, D., Xia, Q., Seligson, M., Shinoda, G., Xie, W., Cahan, P., Wang, L., Ng, S. C., Tintara, S., Trapnell, C., Onder, T., Loh, Y. H., Mikkelsen, T., Sliz, P., Teitell, M. A., Asara, J. M., Marto, J. A., Li, H., Collins, J. J. & Daley, G. Q. 2016.
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.
Cell Stem Cell
. [Epub ahead of print]

Yu, S., Ma, H., Ow, J. R., Goh, Z., Chiang, R., Yang, H., Loh, Y. H.* & Wu, Q. 2016.
Zfp553 Is Essential for Maintenance and Acquisition of Pluripotency.
Stem Cells Development
, 25, 55-67. [Epub 2015 Dec 15]
*As Co-corresponding author

Yang, B. X., El Farran, C. A., Guo, H. C., Yu, T., Fang, H. T., Wang, H. F., Schlesinger, S., Seah, Y. F., Goh, G. Y., Neo, S. P., LI, Y., Lorincz, M. C., Tergaonkar, V., Lim, T. M., Chen, L., Gunaratne, J., Collins, J. J., Goff, S. P., Daley, G. Q., LI, H., Bard, F. A. & Loh, Y. H.* 2015.
Systematic identification of factors for provirus silencing in embryonic stem cells.
Cell, 163, 230-45. [Epub 2015 Sep 10]
*As Corresponding author

Seah, Y. F., El Farran, C. A., Warrier, T., Xu, J. & Loh, Y. H.* 2015.
Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges.
International Journal of Molecular Sciences, 16, 28614-34.
*As Corresponding author

Maury, J. J., El Farran, C. A., NG, D., Loh, Y. H., BI, X., Bardor, M. & Choo, A. B. 2015.
RING1B O-GlcNAcylation regulates gene targeting of polycomb repressive complex 1 in human embryonic stem cells.
Stem Cell Research
, 15, 182-9.

Tan, H. K., Toh, C. X., Ma, D., Yang, B., Liu, T. M., Lu, J., Wong, C. W., Tan, T. K., Li, H., Syn, C., Tan, E. L., Lim, B., Lim, Y. P., Cook, S. A. & Loh, Y. H.* 2014.
Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking.
Stem Cells Translational Medicine
, 3, 586-98. [Epub 2014 Mar 19]
*As Corresponding author

Ma, H., Ow, J. R., Tan, B. C., Goh, Z., Feng, B., Loh, Y. H., Fedele, M., Li, H. & Wu, Q. 2014.
The dosage of Patz1 modulates reprogramming process.
Science Report
, 4, 7519.

Ma, H., Ng, H. M., Teh, X., Li, H., Lee, Y. H., Chong, Y. M., Loh, Y. H., Collins, J. J., Feng, B., Yang, H. & Wu, Q. 2014.
Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency.
PLOS Genetics
, 10, e1004038.

Lu, Y., Loh, Y. H.*, Li, H., Cesana, M., Ficarro, S. B., Parikh, J. R., Salomonis, N., Toh, C. X., Andreadis, S. T., Luckey, C. J., Collins, J. J., Daley, G. Q. & Marto, J. A. 2014.
Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells.
Cell Stem Cell
, 15, 92-101. [Epub 2014 May 7]
*As Co-first author

Faucon, P.C., Pardee, K., Li, H., Loh, Y.H., Wang, X. 2014.
Gene Networks of Fully Connected Triads with Complete Auto-Activation Enable Multistability and Stepwise Stochastic Transitions.
PLOS One 9(7):e102873.

Wen, B., Wu, H., Loh, Y. H.*, Briem, E., Daley, G. Q. & Feinberg, A. P. 2012.
Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions.
BMC Genomics, 13, 566. *As Co-first author

Loh, Y. H., Yang, J. C., De Los Angeles, A., Guo, C., Cherry, A., Rossi, D. J., Park, I. H. & Daley, G. Q. 2012. Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA.
Current Protocol in Stem Cell Biology, Chapter 4, Unit4A 5.

De Los Angeles, A., Loh, Y. H., Tesar, P. J. & Daley, G. Q. 2012.
Accessing naive human pluripotency.
Current Opinion in Genetics and Development
, 22, 272-82.

Brock, A., Goh, H. T., Yang, B., LU, Y., LI, H. & Loh, Y. H.* 2012.
Cellular reprogramming: a new technology frontier in pharmaceutical research.
Pharmaceutical Research, 29, 35-52. Epub 2011 Nov 9.
*As Corresponding author

Bajpai, V. K., Mistriotis, P., Loh, Y. H., Daley, G. Q. & Andreadis, S. T. 2012.
Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.
Cardiovascular Research
, 96, 391-400. [Epub 2012 Aug 31]

Loh, Y. H., Yang, L., Yang, J. C., Li, H., Collins, J. J. & Daley, G. Q. 2011.
Genomic approaches to deconstruct pluripotency.
Annual Review Genomics Human Genetics
, 12, 165-85.

Kim, K., Zhao, R., Doi, A., Ng, K., Unternaehrer, J., Cahan, P., Huo, H., Loh, Y. H., Aryee, M. J., Lensch, M. W., Li, H., Collins, J. J., Feinberg, A. P. & Daley, G. Q. 2011.
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
Nature Biotechnology, 29, 1117-9.

Gore, A., Li, Z., Fung, H. L., Young, J. E., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M. A., Kiskinis, E., Lee, J. H., Loh, Y. H., Manos, P. D., Montserrat, N., Panopoulos, A. D., ruiz, S., Wilbert, M. L., Yu, J., Kirkness, E. F., Izpisua Belmonte, J. C., Rossi, D. J., Thomson, J. A., Eggan, K., Daley, G. Q., Goldstein, L. S. & Zhang, K. 2011.
Somatic coding mutations in human induced pluripotent stem cells.
Nature, 471, 63-7.

Ang, W. X., Toh, C. X., NG, H. H. & Loh, Y. H.* 2011.
Reproductive medicine gets a new tool.
Journal of Molecular Cell Biology
, 3, 320-1.
*As Corresponding author

Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y. H.*, Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., Daley, G. Q., Brack, A. S., Collins, J. J., Cowan, C., Schlaeger, T. M. & Rossi, D. J. 2010.
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
Cell Stem Cell
, 7, 618-30. [Epub 2010 Sep 30]
*As Co-second author.
Featured as Top 10 Breakthroughs of the Year, Science magazine 330(6011)

Loh, Y. H., Hartung, O., Li, H., Guo, C., Sahalie, J. M., Manos, P. D., Urbach, A., Heffner, G. C., Grskovic, M., Vigneault, F., Lensch, M. W., Park, I. H., Agarwal, S., Church, G. M., Collins, J. J., Irion, S. & Daley, G. Q. 2010. Reprogramming of T cells from human peripheral blood.
Cell Stem Cell
, 7, 15-9.
Featured on Cover page & Preview by Shinya Yamanaka, Cell Stem Cell 7(2)

Loewer, S., Cabili, M. N., Guttman, M., Loh, Y. H., Thomas, K., Park, I. H., Garber, M., Curran, M., Onder, T., Agarwal, S., Manos, P. D., Datta, S., Lander, E. S., Schlaeger, T. M., Daley, G. Q. & Rinn, J. L. 2010.
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Nature Genetics, 42, 1113-7. [Epub 2010 Nov 7]
Featured in Preview by Huck-Hui Ng, Nature Genetics 42(12)

Agarwal, S., Loh, Y. H., Mcloughlin, E. M., Huang, J., Park, I. H., Miller, J. D., Huo, H., Okuka, M., Dos Reis, R. M., Loewer, S., Ng, H. H., Keefe, D. L., Goldman, F. D., Klingelhutz, A. J., Liu, L. & Daley, G. Q. 2010.
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.
, 464, 292-6. [Epub 2010 Feb 17]
Featured in MIT Technology Review 2010 Feb 18

Yuan, P., Han, J., Guo, G., Orlov, Y. L., Huss, M., Loh, Y. H., Yaw, L. P., Robson, P., Lim, B. & Ng, H. H. 2009.
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells.
Genes and Development
, 23, 2507-20.

Loh, Y. H., Agarwal, S., Park, I. H., Urbach, A., Huo, H., Heffner, G. C., Kim, K., Miller, J. D., Ng, K. & Daley, G. Q. 2009.
Generation of induced pluripotent stem cells from human blood.
, 113, 5476-9. [Epub 2009 Mar 18]
Featured in Faculty of 1000 Medicine

Feng, B., Jiang, J., Kraus, P., Ng, J. H., Heng, J. C., Chan, Y. S., Yaw, L. P., Zhang, W., Loh, Y. H., Han, J., Vega, V. B., Cacheux-Rataboul, V., Lim, B., Lufkin, T. & Ng, H. H. 2009.
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.
Nature Cell Biology, 11, 197-203.
[Epub 2009 Jan 11]
Featured in Faculty of 1000 Biology

Chan, E. M., Ratanasirintrawoot, S., Park, I. H., Manos, P. D., Loh, Y. H., Huo, H., Miller, J. D., Hartung, O., Rho, J., Ince, T. A., Daley, G. Q. & Schlaeger, T. M. 2009.
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.
Nature Biotechnology, 27, 1033-7. [Epub 2009 Oct 11]
Featured in Preview, Nature Biotechnology 27

Ng, J. H., Heng, J. C., Loh, Y. H.* & Ng, H. H. 2008.
Transcriptional and epigenetic regulations of embryonic stem cells.
Mutation Research
, 647, 52-8. *As Co-Corresponding author

Loh, Y. H.*, Ng, J. H. & Ng, H. H. 2008.
Molecular framework underlying pluripotency.
Cell Cycle
, 7, 885-91.
Invited Review *As Corresponding author

Jiang, J., Chan, Y. S., Loh, Y. H.*, Cai, J., Tong, G. Q., Lim, C. A., Robson, P., Zhong, S. & Ng, H. H. 2008.
A core Klf circuitry regulates self-renewal of embryonic stem cells.
Nature Cell Biology
, 10, 353-60. [Epub 2008 Feb 10] *As Co-second author

Chen, X., Xu, H., Yuan, P., Fang, F., Huss, M., Vega, V. B., Wong, E., Orlov, Y. L., Zhang, W., Jiang, J., Loh, Y. H., Yeo, H. C., Yeo, Z. X., Narang, V., Govindarajan, K. R., Leong, B., Shahab, A., Ruan, Y., Bourque, G., Sung, W. K., Clarke, N. D., Wei, C. L. & Ng, H. H. 2008.
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.
Cell, 133, 1106-17.
Featured in Faculty of 1000 Biology

Loh, Y. H., Zhang, W., Chen, X., George, J. & Ng, H. H. 2007.
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.
Genes and Development, 21, 2545-57.
Featured in Research Highlights, Nature Reviews Genetics 8 & Preview by Hitoshi Niwa Genes and Development 21

Lim, L. S., Loh, Y. H.*, Zhang, W., Li, Y., Chen, X., Wang, Y., Bakre, M., Ng, H. H. & Stanton, L. W. 2007.
Zic3 is required for maintenance of pluripotency in embryonic stem cells.
Molecular Biology of the Cell, 18, 1348-58.
[Epub 2007 Jan 31] *As Co-first author

Wu, Q., Chen, X., Zhang, J., Loh, Y. H., Low, T. Y., Zhang, W., Zhang, W., Sze, S. K., Lim, B. & Ng, H. H. 2006. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells.
Journal of Biological Chemistry, 281, 24090-4. [Epub 2006 Jul 13]

Loh, Y. H., Wu, Q., Chew, J. L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong, K. Y., Sung, K. W., Lee, C. W., Zhao, X. D., Chiu, K. P., Lipovich, L., Kuznetsov, V. A., Robson, P., Stanton, L. W., Wei, C. L., Ruan, Y., Lim, B. & Ng, H. H. 2006.
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Nature Genetics
, 38, 431-40. [Epub 2006 Mar 5]
Featured in Research Highlights, Nature Methods 3(5) and Faculty of 1000 Biology

Rodda, D. J., Chew, J. L., LIM, L. H., Loh, Y. H., Wang, B., Ng, H. H. & Robson, P. 2005.
Transcriptional regulation of nanog by OCT4 and SOX2.
Journal of Biological Chemistry, 280, 24731-7. [Epub 2005 Apr 27]

Chew, J. L., Loh, Y. H.*, Zhang, W., Chen, X., Tam, W. L., Yeap, L. S., Li, P., Ang, Y. S., Lim, B., Robson, P. & Ng, H. H. 2005.
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Molecular and Celullar Biology, 25, 6031-46.

* As Co-first author


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