Jonathan Yuin-Han LOH
                       
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  Recent Publications  
 
Lu Y, Loh YH*, Li H, Cesana M, Ficarro SB, Parikh JR, Salomonis N, Toh CX, Andreadis ST, Luckey CJ, Collins JJ, Daley GQ, Marto JA (2014)
Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells.
Cell Stem Cell
Epub 2014 May 7. *Co-first author

Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH* (2014)
Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking.
Stem Cells Translational Medicine 3(5):586-598. Epub 2014 Mar 19. *Corresponding author

Ma H, Ng HM, Teh X, Li H, Lee YH, Chong YM, Loh YH, Collins JJ, Feng B, Yang H, Wu Q. (2014) Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency.
PLoS Genetics 10(2):e1004038.

Bo W, Wu, H, Loh YH*, Briem E, Daley GQ, Feinberg AP (2012)
Euchromatin Islands in Large Heterochromatin Domains are Enriched for CTCF Binding and Differentially DNA-methylated Regions.
BMC Genomics 13:566. *Co-first author

Bajpai V.K, Mistriotis P, Loh YH, Daley GQ, Andreadis ST (2012)
Functional vascular smooth muscle cells derived from human induced pluripotent stem cells.
Cardiovascular Research 1;96(3):391-400. Epub 2012 Aug 31.

De Los Angeles A, Loh YH, Tesar PJ, Daley GQ. (2012).
Accessing naive human pluripotency.
Current Opinion in Genetics and Development
2012 Mar 29. [Epub ahead of print].

Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ. (2012)
Excision of a viral reprogramming cassette by delivery of synthetic cre mRNA.
Current Protocols in Stem Cell Biology Chapter 4:Unit4A.5.

Kim K, Zhao R, Doi A, Ng K, Unternaehrer J, Cahan P, Huo H, Loh YH, Aryee MJ, Lensch MW, Li H, Collins JJ, Feinberg AP, Daley GQ. (2011).
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
Nature Biotechnology. 29(12):1117-9.

Ang WX, Toh CX, Ng HH, Loh YH.* (2011).
Reproductive medicine gets a new tool.
Journal of Molecular Cell Biology 3(6), 320-321. Epub 2011 Nov 24.*Corresponding author

Brock A, Goh HT, Yang B, Lu Y, Li H, Loh YH.* (2012).
 Cellular reprogramming: a new technology frontier in pharmaceutical research.
Pharmaceutical Research 29(1). 35-52. Epub 2011 Nov 9. *Corresponding author

Loh YH, Yang L, Yang JC, Li H, Collins JJ, Daley GQ. (2011).
Genomic approaches to deconstruct pluripotency.
Annual Review of Genomics and Human Genetics 12:165-85.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. (2011).
Somatic coding mutations in human induced pluripotent stem cells.
Nature 471(7336):63-7.

Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL. (2010).
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Nature Genetics 42(12):1113-7. Epub 2010 Nov 7.
Featured in Preview by Huck-Hui Ng, Nature Genetics 42(12)

Warren L, Manos PD, Ahfeldt T, Loh YH*, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. (2010).
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.  
Cell Stem Cell
7(5):618-30. Epub 2010 Sep 30. *Co-second author.
Featured as Top 10 Breakthroughs of the Year, Science magazine 330(6011)

Loh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, Irion S, Daley GQ. (2010).
Reprogramming of T Cells from Human Peripheral Blood.
Cell Stem Cell 7(1), 15-19.
Featured on Cover page & Preview by Nobelist Shinya Yamanaka, Cell Stem Cell 7(2)

Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. (2010).
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.
Nature 464 (7286), 292-296. Epub 2010 Feb 17.
Featured in MIT Technology Review 2010 Feb 18

Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH. (2009).
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells.
Genes and Development 23 (21), 2507-2520.

Chan EM, Ratanasirintrawoot S, Park IH, Manos PD, Loh YH, Huo H, Miller JD, Hartung O, Rho J, Ince TA, Daley GQ, Schlaeger TM. (2009).
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.
Nature Biotechnology. 27(11), 1033-1037. Epub 2009 Oct 11.
Featured in Preview, Nature Biotechnology 27

Loh YH, Agarwal S, Park IH, Urbach A, Huo H, Heffner GC, Kim K, Miller JD, Ng K, Daley GQ. (2009). Generation of induced pluripotent stem cells from human blood.
Blood. 113, 5476-5479. Epub 2009 Mar 18.
Featured in Faculty of 1000 Medicine

Feng B, Jiang J, Kraus P, Ng JH, Heng JC, Chan YS, Yaw LP, Zhang W, Loh YH, Han J, Vega VB, Cacheux-Rataboul V, Lim B, Lufkin T, Ng HH. (2009).
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nature Cell Biology. 11(2):197-203. Epub 2009 Jan 11.
Featured in Faculty of 1000 Biology

Ng JH, Heng JC, Loh YH*, Ng HH. (2008)
Transcriptional and epigenetic regulations of embryonic stem cells.
Mutation Research. 1;647(1-2):52-8. Epub 2008 Aug 20. Invited Review
*Corresponding author

Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH. (2008)
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.
Cell 13;133(6):1106-17. Featured in Faculty of 1000 Biology

Loh YH*, Ng JH, Ng HH. (2008).
Molecular framework underlying pluripotency
Cell Cycle 7:7, 1-8. Invited Review *Corresponding author

Jiang J, Chan YS, Loh YH*, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH. (2008).
A core Klf circuitry that regulates self-renewal of embryonic stem cells.
Nature Cell Biology 10, 353-360. Epub 2008 Feb 10. *Co-second author

Loh YH, Zhang W, Chen X, George J, Ng HH. (2007).
Jmjd1a and Jmjd2c histone H3 lysine 9 demethylases regulate self-renewal in embryonic stem cells.
Genes and Development 21, 2545-2557.
Featured in Research Highlights, Nature Reviews Genetics 8 & Genes and Development 21

Lim LS, Loh YH*, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW. (2007).
Zic3 Is Required for Maintenance of Pluripotency in Embryonic Stem Cells.
Molecular Biology of the Cell
18, 1348-1358. Epub 2007 Jan 31. *Co-first author

Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH. (2006).
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells.
Journal of Biological Chemistry
281(34), 24090-24094. Epub 2006 Jul 13.

Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. (2006).
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Nature Genetics 38, 431–440. Epub 2006 Mar 5. Featured in Research Highlights, Nature Methods 3(5) and Faculty of 1000 Biology

Chew JL, Loh YH*, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH. (2005).
 Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Molecular and Cellular Biology 25, 6031-6046. * Co-first author

Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P. (2005).
Transcriptional regulation of Nanog by OCT4 and SOX2.
Journal of Biological Chemistry 280, 24731–24737. Epub 2005 Apr 27.

 

 
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