Humanized Mouse Unit
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Dahai Zheng, Boon-Seng Soh, Lu Yin, Guangan Hu, Qingfeng Chen, Hyungwon Choi, Jongyoon Han, Vincent T. K. Chow, Jianzhu Chen.
Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro.
Scientific Reports, 2017, doi:10.1038/srep41661. (IF= 5.525)

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li J, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan J, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG.
CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.
J Exp Med. 2016 Oct 10. [Epub ahead of print]. (IF=11.24)

Xia, Jinxing, Hu, Zheng, Yoshihara, Satoshi, Li, Yuying, Jin, Chun-Hui, Tan, Shulian, Li, Wei, Chen, Qingfeng, Sykes, Megan, Yang, Yong-Guang,
Modeling human leukemia immunotherapy in humanized mice.
EBioMedicine (2016), doi:10.1016/j.ebiom.2016.06.028 Epub 2016 Jun 23.

Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng OL, Nardin A, Chen Q, Abastado JP, Chew V. Interaction between tumor-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.
Gut, 2015, Dec 2015, doi:10.1136/gutjnl-2015-310814. (IF=14.66).

Chen Q#, Ye W, Tan WJ, Yong K, Liu M, Tan SQ, Loh E, Chang KTE, Tan TC, Preiser PR, Chen J.
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.Scientific Reports, 2015, doi:10.1038/srep15118. (IF= 5.578)

L.-E. Wai, C.T. Keng, D. Zheng, A. Tan-Garcia, E. Ceccarello, C. Tham, A.T. Tanoto, A. Bertoletti, Q. Chen#.
P0483 : Changes in liver immunity upon HBV infection: a comparison of humanised mice and humans.
Journal of Hepatology, 04/2015; 62:S495. DOI:10.1016/S0168-8278(15)30691-7. (IF=10.40)

Amaladoss, A, Chen Q, Liu M, Dummler S, Dao M, Suresh S, Chen J, Preiser PR.
De Novo Generated Human Red Blood Cells in Humanized Mice Support Plasmodium falciparum Infection.
Plos One, 2015, DOI: 10.1371/journal.pone.0129825. (IF=3.234)

Yong K, Keng CT, Tan SQ, Loh E, Chang KTE, Tan TC, Hong W, Chen Q#.
Human CD34loCD133lo Fetal Liver Cells Support the Expansion of Human CD34hiCD133hi Hematopoietic Stem Cells.
Molecular and Cellular Immunology, 2015, doi:10.1038/cmi.2015.43. (IF=4.112)

Bae KH, Lee F, Xu KM, Keng CT, Tan SY, Tan YJ, Chen Q#, Kurisawa M.
Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs.
Biomaterials, 2015, doi:10.1016/j.biomaterials.2015.06.008. (IF=8.557)

Keng CT, Sze CW, Zheng DH, Zheng ZQ, Yong K, Tan SQ, Ong JY, Tan SY, Loh E, Upadya MH, Kuick CH, Hotta H, Lim SG, Tan TC, Chang KTE, Hong W, Chen J, Tan YJ, Chen Q#. Characterization of Liver Pathogenesis, Human Immune Responses and Drug Testing in a Humanized Mouse Model of Hepatitis C Virus Infection.
Gut. 2015, doi:10.1136/gutjnl-2014-307856. (IF=14.66)

Hong X, Nguyen HT, Chen Q, Zhang R, Hagman Z, Voorhoeve PM, Cohen SM.
Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover.
EMBO J. 2014 Nov 3;33(21):2447-57. (IF=10.748)

Nguyen HT, Hong X, Tan S, Chen Q, Chan L, Fivaz M, Cohen SM, Voorhoeve PM.
Viral Small T Oncoproteins Transform Cells by Alleviating Hippo-Pathway-Mediated Inhibition of the YAP Proto-oncogene.
Cell Rep. 2014 Aug 7;8(3):707-13. (IF=7.215)

Xue C, Kwek KYC, Chan JKY, Chen Q, and Lim M.
The hollow fiber bioreactor as a stroma-supported, serum-free ex vivo expansion platform for human umbilical cord blood cells. Biotechnology Journal. 2014. Jul;9(7):980-9. (IF=3.446)

Chen Q, Amaladoss A, Ye W, Liu M, Dummler S, Kong F, Wong LH, Loo HL, Loh E, Tan SQ, Tan TC, Chang KTE, Dao M, Suresh S, Preiser PR, Chen J.
Human Natural Killer Cells Control Plasmodium falciparum Infection by Eliminating Infected Red Blood Cells.
Proc Natl Acad Sci U S A. 2014. Jan 28;111(4):1479-84. (IF=9.737)

Loh K, Ang LT, Zhang J, Kumar V, Ang J, Auyeong JQ, Lee KL, Nichane M, Poellinger L, Chen Q, Prabhakar S, Weissman IL, Lim B.
Efficient Endoderm Induction from Human Pluripotent Stem Cells by Logically Directing Signals Controlling Lineage Bifurcations.
Cell Stem Cell. 2014 Feb 6;14(2):237-52. (IF=27.361)

Sridharan A, Chen Q, Tang KF, Ooi EE, Hibberd ML, Chen J.
Inhibition of Megakaryocyte Development in the Bone Marrow Underlies Dengue Virus-induced Thrombocytopenia in Humanized Mice.
Journal of Virology. 2013 Nov;87(21):11648-58. (IF=5.076)

Li Y*, Chen Q*, Zheng D, Yin L, Chionh YH, Wong LH, Tan SQ, Tan TC, Chan JK, Alonso S, Dedon PC, Lim B, Chen J.
Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF (CSF-1) in Humanized Mice.
Journal of Immunology. 2013 Sep 15;191(6):3192-9. (IF=5.520)

Chen, Q#. and Chen, J. (2013).
Serial Transfer of Human Hematopoietic and Hepatic Stem/progenitor Cells.
Bio-protocol 3(23): e992. .

Chen, Q#. and Chen, J. (2013).
Isolation of CD34+ Cells from Human Fetal Liver and Cord Blood.
Bio-protocol 3(23): e991. .

Chen Q, Khoury M, Limmon G, Choolani M, Chan JKY, Chen J.
Human Fetal Hepatic Stem Cells Are Distinct from, but Closely Related to, Hematopoietic Stem Cells.
Stem Cells. 2013 Jun;31(6):1160-9. (IF=7.9)

He F, Kiener TK, Lim XF, Tan Y, Raj KV, Tang M, Chow VT, Chen Q, Kwang J.
Development of A Sensitive and Specific Epitope-Blocking ELISA for Universal Detection of Antibodies to Human Enterovirus 71 Strains.
Plos One, 2013;8(1):e55517. (IF=3.730)

Chen Q, He F, Kwang J, Chan JKY, Chen J.
GM-CSF and IL-4 Stimulate Antibody Responses in Humanized Mice by Promoting T, B and Dendritic Cell Maturation.
Journal of Immunology. 2012 Dec 1;189(11):5223-9. (IF=5.520)

Drake A*, Chen Q*, Chen J.
Engineering Humanized Mice for Improved Hematopoietic Reconstitution.
Cell Mol Immunol. 2012 May;9(3):215-24. (IF= 3.419)

Khoury M, Drake A, Chen Q et al.
Mesenchymal Stem Cells Secreting Angiopoietin-Like-5 Support Efficient Expansion of Human Hematopoietic Stem Cells Without Compromising Their Repopulating Potential.
Stem Cells Dev. 2011 August; 20(8): 1371–1381. (IF= 4.670)

Chen Q, Khoury M, Chen J.
Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice.
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21783-8. (IF=9.737)

Chen Q, Wei H, Sun R et al.
Therapeutic RNA silencing of CX3CL1 gene prevents mice from adenovirus vector-induced acute liver injury.
Hepatology. 2008 Feb;47(2):648-58. (IF=12.003)
Ren T*, Chen Q*, Tian Z, Wei H.
Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice.
Biochem Biophys Res Commun. 2007 Dec 28; 364(4):978-84. (IF=2.500)

Zhang X, Wei H, Chen Q et al. Activation of human natural killer cells by recombinant membrane expressed fractalkine on the surface of tumor cells.
Oncol Rep. 2007 Jun; 17(6):1371-5. (IF= 2.297)

Isolation and characteristics of murine hepatic innate lymphocytes. Z Dong, H Wei, J Wang, D Luo, L Zhang, Q Chen, Z Tian.
Academic journal of Second Military Medical College. 2001, 23 (10), 1095-1098.
Co-first author; # Corresponding author.

Patents filed:

1. Methods Of Producing Humanized Non-Human Mammals. WIPO Publication number: WO/2011/002727; Europe patent number: EP2449094. US patent number: US2012-0157667. Japan Patent Application No.: 2012-517837. China patent publication number: CN102725400A. Licensed in 2015 Feb 24th. MIT Case No. 14234D.

2. Methods Of Reconstituting Human Hepatocytes And Human Hematopoietic Cells In Non-Human Mammals. WIPO Publication number: WO/2012/005690; PCT/SG2011/000234

3. Humanized Non-Human Model. U.S. Application NO.: 61/221,438.

4. A Humanized Non-Human Mammal Model of Malaria and Uses Thereof. WIPO Publication number: WO/2012/051572; PCT/US2011/056425

5. Use of Humanized Mice to Determine Toxicity. US publication number US-2015-0007357 A1. : 61/567,466. China Patent Application No.: 2012800689704. Singapore Patent Application No. 11201402112R. EP Application No.:  12854884.9. Licensed in 2015 Feb 24th. MIT Case No. 15267D.

6. A Humanized Mouse Model For Study Of Bona Fide Hepatitis Virus Infection And Use Thereof. PCT Application number IMC/P/07941/01/PCT.

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