Humanized Mouse Unit
                       
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  Qingfeng CHEN  
  Lab Location: #5-15B

email:
qchen@imcb.a-star.edu.sg
tel: 65869873
 
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  Key Publications  
 


Chen Q#, Ye W, Tan WJ, Yong K, Liu M, Tan SQ, Loh E, Chang KTE, Tan TC, Preiser PR, Chen J.
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific Reports, 2015, doi:10.1038/srep15118. (IF= 5.578)

Yong K, Keng CT, Tan SQ, Loh E, Chang KTE, Tan TC, Hong W, Chen Q#.
Human CD34loCD133lo Fetal Liver Cells Support the Expansion of Human CD34hiCD133hi Hematopoietic Stem Cells.
Molecular and Cellular Immunology, 2015, doi:10.1038/cmi.2015.43.

Bae KH, Lee F, Xu KM, Keng CT, Tan SY, Tan YJ, Chen Q#, Kurisawa M.
Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs.
Biomaterials, 2015, doi:10.1016/j.biomaterials.2015.06.008.

Keng CT, Sze CW, Zheng DH, Zheng ZQ, Yong K, Tan SQ, Ong JY, Tan SY, Loh E, Upadya MH, Kuick CH, Hotta H, Lim SG, Tan TC, Chang KTE, Hong W, Chen J, Tan YJ, Chen Q#.
Characterization of Liver Pathogenesis, Human Immune Responses and Drug Testing in a Humanized Mouse Model of Hepatitis C Virus Infection.
Gut. 2015, doi:10.1136/gutjnl-2014-307856.

Chen Q, Amaladoss A, Ye W, Liu M, Dummler S, Kong F, Wong LH, Loo HL, Loh E, Tan SQ, Tan TC, Chang KTE, Dao M, Suresh S, Preiser PR, Chen J.
Human Natural Killer Cells Control Plasmodium falciparum Infection by Eliminating Infected Red Blood Cells.
Proc Natl Acad Sci U S A. January 2014.

Loh K, Ang LT, Zhang J, Kumar V, Ang J, Auyeong JQ, Lee KL, Nichane M, Poellinger L, Chen Q, Prabhakar S, Weissman IL, Lim B.
Dynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells.
Cell Stem Cell. Online 09 Jan 2014.

Li Y*, Chen Q*, Zheng D, Yin L, Chionh YH, Wong LH, Tan SQ, Tan TC, Chan JK, Alonso S, Dedon PC, Lim B, Chen J.
Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF (CSF-1) in Humanized Mice.
Journal of Immunology 2013 Aug 9. (co-first author)

Chen Q, Khoury M, Limmon G, Choolani M, Chan JK, Chen J.
Human Fetal Hepatic Progenitor Cells Are Distinct from, but Closely Related to, Hematopoietic Stem/Progenitor Cells.
Stem Cells. 2013 Feb 13. doi: 10.1002/stem.1359.

Chen Q, He F, Kwang J, Chan JK, Chen J.
GM-CSF and IL-4 Stimulate Antibody Responses in Humanized Mice by Promoting T, B, and Dendritic Cell Maturation.
Journal of Immunology. 2012 Dec 1;189(11):5223-9.

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    Qingfeng CHEN
 


Qingfeng Chen received his B.S. in 2003 and Ph.D in June 2008 from University of Science and Technology of China. In July 2008, he joined in Singapore-MIT Alliance for Research and Technology (SMART) to pursue postdoctoral research on developing humanized mouse models. In 2010, he was promoted as research scientist in SMART. He Joined in Institute of Molecular and Cell Biology, A*STAR as a group leader in January 2012 to establish humanized mouse unit. He is currently a Principal Investigator in IMCB, joint Principal Investigator in National Cancer Centre Singapore and adjunct assistant professor in Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore. Qingfeng Chen is also an awardee of Gilead Sciences International Research Scholar and Singapore National Research Foundation Fellowship. His research interest is developing humanized mouse models for the study of human infectious diseases, cancers, autoimmune diseases and stem cells.

       
 
       
    Humanized Mouse Unit (HMU)
   


Humanized mouse refers to mouse stably reconstituted with human cells and tissues. Our mission is to develop humanized mouse models to closely recapitulate in vivo human biology to study human diseases and drug development. Currently our research areas cover: