Adrian Kee Keong TEO 
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  Recent Publications  

Loo, S.W.L., Lau, H.H., Jasmen, J., Lim, C.S., and Teo, K.K.A. (2017).
An arduous journey from human pluripotent stem cells to functional pancreatic β-cells.
Diabetes, Obesity and Metabolism, in press

Isaac, A.*, Kodali, A.*, Nguyen, L., Teo, K.K.A., Chang, C.W., Karnani, N., Ng, K.L., Chong, Y.S., Gluckman, P.D., and Stunkel, W. (2017).
Gestational diabetes alters functions in offspring's umbilical cord cells with implications for cardiovascular health.
Endocrinology, in press.

Valdez, I.A., Dirice, E., Gupta, M.K., Shirakawa, J., Teo, K.K.A.*, and Kulkarni, R.N.* (2016).
Proinflammatory cytokines induce endocrine differentiation in pancreatic ductal cells via STAT3-dependent NGN3 activation.
Cell Reports 15, 1-11.
*Co-senior and Co-corresponding authors

Teo, K.K.A.*, Lau, H.H., Valdez, I.A., Dirice, E., Tjora, E., Raeder, H., and Kulkarni, R.N.* (2016).
Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia.
Stem Cell Reports 6, 357-367.
*Corresponding authors

Santosa, M., Low S.J.B., Pek M.Q.N., and Teo, K.K.A. (2016).
Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands.
Front. Endocrinol. 6, 194.

Gupta, M.K., Teo, K.K.A., Rao, T.N., Bhatt, S., Kleinridders, A., Shirakawa, J., Takatani, T., Hu, J., De Jesus, D.F., Windmueller, R., Wagers, A.J., and Kulkarni, R.N. (2015).
Excessive cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts.
Stem Cells Transl Med, 4, 1101-1108.

Teo, K.K.A.*, Gupta, M.K., Doria, A., and Kulkarni, R.N.* (2015).
Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools.
Mol Metab 4, 593-604.
*Corresponding authors

Teo, K.K.A., Tsuneyoshi, N., Hoon, S., Tan, E.-K., Stanton, L.W., Wright, C.V., and Dunn, N.R. (2015).
PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells.
Stem Cell Reports 4, 578-590.

Valdez, I.A.#, Teo, K.K.A.#*, and Kulkarni, R.N.* (2015).
Cellular stress drives pancreatic plasticity.  
Sci. Transl. Med.
 7, 273ps2.
#First authors
*Corresponding authors

Teo, K.K.A.*, Valdez, I.A., Dirice, E., and Kulkarni, R.N.* (2014).
Comparable generation of Activin-induced definitive endoderm via additive Wnt or BMP signalling in absence of serum. 
Stem Cell Reports
  3, 5-14.
*Corresponding authors

Dirice, E., Kahraman, S., Jiang, W., El Ouaamari, A., De Jesus, D., Teo, K.K.A., Hu, J., Kawamori, D., Gaglia, J., Mathis, D., and Kulkarni, R.N. (2014).
Soluble factors secreted by T-cells promote β cell proliferation.
Diabetes 63, 188-202.

Teo, K.K.A., Wagers, A.J., and Kulkarni, R.N. (2013).
New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism.
Cell Metabolism 18, 775-791.

Teo, K.K.A., Windmueller, R., Johansson, B.B., Dirice, E., Njolstad, P.R., Tjora, E., Raeder, H., and Kulkarni, R.N. (2013).
Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young.
J Biol Chem 288, 5353-5356.

Teo, K.K.A., and Kulkarni, R.N. (2012).
Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.
EMBO J 31, 3956-3957.

Teo, K.K.A.*, Ali, Y.*, Wong, K.Y., Chipperfield, H., Sadasivam, A., Poobalan, Y., Tan, E.-K., Wang, S.-T., Abraham, S., Tsuneyoshi, N., Stanton, L.W., and Dunn, N.R. (2012).
Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells.
Stem Cells 30, 631-642.
*Equal contribution

Brown, S., Teo, A., Pauklin, S., Hannan, N., Cho, C.H.-H., Lim, B., Vardy, L., Dunn, N.R., Trotter, M.W.B., Pedersen, R., and Vallier, L. (2011).
Activin/Nodal signalling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors.
Stem Cells 29, 1176-1185.

Teo, K.K.A., Arnold, S.J., Trotter, M.W.B., Brown, S., Ang, L.T., Chng, Z., Robertson, E.J., Dunn, N.R., and Vallier, L. (2011).
Pluripotency factors regulate definitive endoderm specification through Eomesodermin.
Genes Dev 25, 238-250.
Featured in Faculty of 1000 and Perspective in Cell Stem Cell 8, 363-369.

Teo, K.K.A., and Vallier, L. (2010). Emerging use of stem cells in regenerative medicine.
Biochem J 428, 11-23.

Chng, Z., Teo, A., Pedersen, R.A., and Vallier, L. (2010).
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
Cell Stem Cell 6, 59-70.

Vallier, L., Mendjan, S., Brown, S., Chng, Z., Teo, A., Smithers, L.E., Trotter, M.W., Cho, C.H., Martinez, A., Rugg-Gunn, P., Brons, G., and Pedersen, R.A. (2009).
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression.
Development 136, 1339-1349.





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