Christine CHEUNG 
                       
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  Christine CHEUNG  
 
email:
ccheung@imcb.a-star.edu.sg


 
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  Key Publications  
 

.*C Cheung, AS Bernardo, MW Trotter, RA Pedersen & S Sinha.
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Nature Biotechnology, 2012, 30 (2): 165-173. *Featured on cover page and expert commentary

#C Cheung, AS Bernardo, RA Pedersen & #S Sinha.
Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells.
Nature Protocols, 2014, 9: 929–938. #Senior and corresponding author

L Trigueros-M, JM González-G, C Cheung, P Fernández, F Sánchez-Cabo et al. Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity.
Arteriosclerosis, Thrombosis, and Vascular Biology
, 2013, 33:1248-56.

#C Cheung, YT Goh, J Zhang, C Wu, E Guccione. Modelling cerebrovascular pathophysiology in amyloid-β metabolism using neural crest-derived smooth muscle cells.
Cell Reports
, 2014, 9(1):391-401. #Senior and corresponding author
BC Narmada, YT Goh, H Li, S Sinha, H Yu,

#C Cheung. Human stem cell-derived endothelial-hepatic platform for efficacy testing of vascular-protective metabolites from nutraceuticals.
Stem Cells Translational Medicine, 2016, doi: 10.5966/sctm.2016-0129. #Senior and corresponding author

Bargehr, L. Low, C. Cheung, W.G. Bernard, D. Iyer et al.
Embryological origin of human smooth muscle cells influences their ability to support vasculogenesis.
Stem Cells Reports, 2016 Jul; 5(7):946-59.

GJ Ng, AM Quek, C Cheung, TV Arumugam, RC Seet. Stroke biomarkers in clinical practice: A critical appraisal.
Neurochemistry International, 2017, doi:10.1016/j.neuint.2017.01.005.

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  Christine CHEUNG


Dr Christine Cheung received a PhD in Cardiovascular and Stem Cell Medicine from the University of Cambridge, and a BEng (First Class) from Imperial College London. Upon securing the competitive Independent Fellowship in 2012, she started up a research group at the Institute of Molecular and Cell Biology. To further her work, Dr Cheung was awarded the A*STAR Career Development Award grant and the Biomedical Research Council Young Investigator Grant. For her pioneering approach to create organ-specific blood vessels, she was recognised with the Young Investigator Prize from the British Society for Cardiovascular Research. Dr Cheung is also an Assistant Professor at the Lee Kong Chian School of Medicine under the Elite Nanyang Assistant Professorship scheme. Being part of the founding team of Biotech Connection Singapore, the organisation aims to promote life-science innovations and entrepreneurship by fostering interaction between academia, industry and investors.

     
 

Molecular and Vascular Medicine

 


The crux of many diseases lies in the blood vessels. Even though vascular damage often precedes neuronal deficits in certain brain disorders, relatively less attention has been paid to blood vessel pathology in the context of mental health. Our goal is to advance the prevention of cerebrovascular complications by understanding how they affect conditions such as stroke. The main thrusts of our research are

 
Vascular Disease Biomarkers
There remain significant knowledge gaps in the functional interpretation of clinical biomarkers in whether they are causal or a consequence in the disease process. Leveraging on our collaborations with the clinicians, we develop biomarkers of key vascular processes related to stroke and cognitive impairment. Deep-dive elucidation of such molecular signatures would enable us to unravel implicated pathways, and achieve better diagnostics for early intervention.

Neurovascular Ageing
Blood vessels in various organs could influence differential local tissue responses despite similar genetic and systemic conditions. This may explain why diseases like cerebral amyloid angiopathy and CADASIL uniquely affect the cerebral vasculatures. We aim to interrogate the intrinsic differences of organ-specific blood vessels and determinants that impact predominantly on vascular pathology in the brain. 

Human Stem Cell-Based Platform
Our lab has invented techniques to grow vascular cells from human pluripotent stem cells, resembling those found in brain arteries. By employing genome editing tools and phenotypic assays, we could recapitulate the molecular and cellular changes in cerebrovascular disease. Knowledge of pathogenic mechanisms will pave the way to developing vascular-targeted strategies for neurological disorders.
     

For highly-motivated individuals who are interested in PhD or other research positions in our lab, please send your detailed CV to ccheung@imcb.a-star.edu.sg.