Wanjin HONG  
                       
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  PUBLICATIONS (total citations about 8,100 & H-index of 52)  
 
Selected peer-reviewed original research articles (from 199)

1. Wong, S.H., Low, S.H., and Hong, W.
The 17-residue transmembrane domain of b-galactoside a2,6-sialyltransferase is sufficient for Golgi retention.
J. Cell Biol.
(1992) 117, 245-258. (Identified one of the first few signals for Golgi targeting of sugar transferases)

2. Low, S.H., Tang, B.L., Wong, S.H., and Hong, W.
Selective inhibition of protein targeting to the apical domain of MDCK cells by brefeldin A.
J. Cell Biol. (1992)118, 51-62. (Defined a novel role of brefeldin A in regulating polarized membrane trafficking)

3. Tang, B.L., Wong, S.H., Qi, X.L., Low, S.H. and Hong, W.
Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor.
J. Cell Biol.
(1993) 120, 325-338. (Revealed the molecular and functional conservation of a recycling pathway to retrieve luminal ER proteins)

4. Singh, P., Wong, S.H., and Hong, W.
Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.
The EMBO J. (1994) 13, 3329-3338. (Showed that E2F1 is sufficient for oncogenesis)

5. Griffiths, G., Ericsson, M., Krijnse-Locker, J., Nilsson, T., Goud, B., Soling, H-D., Tang, B.L., Wong, S.H., and Hong, W.
Localization of the KDEL receptor to the Golgi complex and the intermediate compartment in mammalian cells.
J. Cell Biol. (1994) 127, 1557-1574. (Revealed the compartments of the recycling pathway to retrieve luminal ER proteins)

6. Subramaniam, V.N., Krijnse-Locker, J., Tang, B.L., Ericsson, M., Yosoff, A.R.bin M., Griffiths, G., and Hong, W. Monoclonal antibody HFD9 identifies a novel 28 kDa integral membrane protein on the cis-Golgi.   
J. Cell Sci. (1995) 108, 2405-2414. (Identified a novel Golgi membrane protein that turned out to be a novel Golgi SNARE)

7. Singh, P., Coe, J. and Hong, W.
A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor.
Nature
(1995) 374, 562-565. (Identified hBrm as a novel interacting protein for retinoblastoma protein)

8. Lowe, S.L., Wong, S.H. and Hong, W.
The mammalian ARF-like protein 1 (Arl1) is associated with the Golgi complex.
J Cell Sci. (1996) 109, 209-220. (Revealed for the first time that Arl1 GTPase is present in the Golgi apparatus)

9. Subramaniam, V.N., Peter, F., Phil, R., and Hong, W.
GS28, a 28 kDa Golgi SNARE that participates in ER-Golgi transport.
Science (1996) 272, 1161-1163. (Identified one of the first few SNAREs of the Golgi apparatus)

10. Tang, B.L., Peter, F., Krijnse-Locker, J., Low, S.H., Griffiths, G., and Hong, W.
The mammalian homolog of yeast Sec13p is enriched in the intermediate compartment and is essential for protein transport from the endoplasmic reticulum to the Golgi apparatus.
Mol. Cell Biol. (1997) 17, 256-266. (Showed that vesicle budding from the ER occurs in specific sites)

11. Xu, Y., Wong, S.H., Zhang Tao, Subramaniam, V.N., and Hong, W.
GS15, a 15-kilodalton Golgi SNARE homologous to rbet1.  
J. Biol. Chem.
(1997) 272, 20162-20166. (Identified one of a novel SNARE of the Golgi apparatus)

12. Lowe, S.L., Peter, F., Subramaniam, V.N., Wong, S.H., and Hong, W.
A SNARE involved in protein transport through the Golgi apparatus.
Nature (1997) 389, 881-884. (Identified one of the first few SNAREs of the Golgi apparatus)

13. Zhang, T., Wong, S.H., Tang, B.L., Xu, Y., Peter, F., and Hong, W.
The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus.
J. Cell Biol.  (1997) 139, 1157-1168. (Defined the function and mechanism of a novel mammalian SNARE)

14. Xu, Y., Hortsman, H., Seet, L.F., Wong, S.H., and Hong, W.
SNX3 regulates endosomal function via its PX domain-mediated interaction with PtdIns(3)P.
Nature Cell Biology (2001) 3, 658-666. (Highlighted in June 29, 2001 issue of Cell 105, 817-820 & Aug issue of Nature Cell Biology 3, E179-182).

15. Mallard, F., Tang, B.L., Galli, T., Antony, C., Xu, Y., Claude, A., Hong, W., Bruno, G., Johannes, L. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. J. Cell Biol. (2002) 156, 653-664.(Established a role of a novel SNARE complex in endosome-Golgi traffic)

16. Loh, E., and Hong, W.
Sec34 is involved in ER-Golgi transport in mammalian cells and exists in a complex(s) containing GTC-90 and ldlB.
J. Biol. Chem.
(2002) 277, 21955 321961. (Identified a novel protein complex called COG in regulating the Golgi apparatus)

17.
Wang, T.L., and Hong, W. 
Inter-organellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein RILP.
Mol. Biol. Cell
(2002) 13, 4317-4332. (Defined a mechanism to regulating lysosomal positioning)

18. Lu, L., and Hong, W. 
Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi.  
Mol. Biol. Cell
(2003) 14, 3767-3781. (Defined the mechanism for Arl1 GTPase to regulate the Golgi apparatus)

19. Wu, M., Lu, L., Hong, W., and Song, H.
Structural Basis of Recruitment of GRIP Domain Golgin-245 by Small GTPase Arl1.
Nature Struct. Mol. Biol.
(2004) 11, 86-94. (Revealed a novel structural mechanism for small GTPases to interact with effector proteins)

20. Loh, E., and Hong, W.
The binary interacting network of the conserved oligomeric Golgi (COG) tethering complex.
J. Biol. Chem.
(2004) 279, 24640-24648. (Defined the interaction map of COG complex)

21. Wang, C.C., Ng, C.P., Lu, L., Atlashkin, V., Zhang, W., Seet, L.F., and Hong, W.
A role of endobrevin/VAMP8 in regulated exocytosis of pancreatic acinar cells.
Dev. Cell (2004) 7, 359-371. (Highlighted in Sept 23, 2004 issue of Nature 431, 412).

22. Wu, M.S., Wang, T.L., Loh, E., Hong, W., and Song, H.W.
Structural basis for recruitment of RILP by small GTPase Rab7.
The EMBO J.
(2005) 24, 1491-1501. (Resolved the structural basis for Rab7 GTPase interaction with its effector)

23. Wang, C.C., Shi, H., Guo, K.,  Ng, C.P.,  Li, J., Gan, B.Q., Liew, H.C., Leinonen, J., Rajaniemi, H., Zhou, Z.H., Zeng, Q., and Hong, W.
VAMP8/endobrevin as a general v-SNARE for regulated exocytosis of the exocrine system.
Mol. Biol. Cell (2007) 18, 1056-1063. (Showed that VAMP8 is a major SNARE responsible for regulated exocytosis of the exocrine system)

24. Tran, T.T.H, Zeng, Q., and Hong, W.
VAMP4 cycles from the surface to the trans-Golgi network via the sorting and recycling endosome.
J. Cell Sci.
(2007) 120, 1028-1041. (Highlighted in This Issue of JCS 120, e601).

25. Chan, S.W., Lim, C.J., Guo, K., Ng, C.P., Lee, I., Hunziker, W., Zeng, Q., and Hong, W.
A role for TAZ in migration, invasion and tumorigenesis of breast cancer cells.
Cancer Res.
(2008) 68, 2592-2598. (Revealed that TAZ is likely a new oncogene for invasive breast cancer)

26. Chan, S.W., Lim, C.J., Loo, L.S., Chong, Y.F., Huang, C., and Hong, Hong, W.
TEADs mediate nuclear retention of TAZ to promote oncogenic transformation.
J. Biol. Chem. (2009) 284, 14347-14358. (Revealed that interaction with TEAD1-4 is important for TAZ to transform cells)

27. Liu, N. S., Loo, L.S., Loh, E., Seet, L.F. and Hong, W.
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.
The EMBO J.
(2009) 28, 3485-3499. (Showed that Tom1L1 is likely a regulated adaptor for EGF-stimulated endocytosis of EGF receptor) (Highlighted by A*STAR research)

28. Wang, C.C., Ng, C.P., Shi, Hong, Liew, H.C., Guo, K., Zeng, Q., and Hong, W.
A role of VAMP8/endobrevin in surface deployment of the water channel aquaporin 2.
Mol. Cell. Biol.
(2010) 30, 333-343. (Showed that VAMP8 is important for vasopressin-induced surface fusion of AQP-2 vesicles)

29. Chen, L.M., Chan, S.W., Zhang, X.Q., Walsh, M., Lim, C.J., Hong, W., Song, H.W.
Structural basis of YAP recognition by TEAD4 in the Hippo pathway.
Genes & Dev.
(2010) 24, 290-300. (Solved the x-ray structure of YAP-TEAD4 protein complex of the Hippo pathway) (Highlighted by A*STAR research)
 
30. Yan Shan Ong, Y.S., Tang, B.L., Loo, L.S., and Hong, W.
p125A exists as part of the mammalian Sec13-Sec31 COPII subcomplex to facilitate ER-Golgi transport.
J. Cell Biol.
(2010) 190, 331-345. (Showed that p125 co-exists with Sec13-Sec31 as a complex to regulate COPII export from the ER) (Highlighted by A*STAR research)

31. Chan, S.W., Lim, C.J., Huang, C.X., Chong, Y.F., Gunaratne, H.J., Hogue, K.A., Blackstock, W.P., Harvey, K.F., and Hong, W.
WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ.
Oncogene
(2011) 30, 600-610. (Showed that Wbp2 is a regulator of the Hippo pathway by acting as a positive factor for TAZ and YAP) (Highlighted by A*STAR research)
 
32. Cai, L., Loo, L.S., and Hong, W.
Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-methyl-D-aspartate (NMDA) Receptor 2C (NR2C).
Mol. Cell. Biol. (2011) 31, 1734-1747. (Defined that SNX27 is a general endosomal sorting protein for surface proteins with PDZ-binding motifs) (highlighted by A*STAR research)

33. Chan, S.W., Lim, C.J., Chong, Y.F., Venkatesan Pobbati, A., Huang, C.X., and Hong, W.
Hippo pathway-independent regulation of TAZ and YAP by Angiomotin family.
J. Biol. Chem.
(2011) 286, 7018-7026. (Identified angiomotin as a novel regulator of TAZ and YAP in the Hippo pathway) (highlighted by A*STAR research)

34. Pobbati, A.V., Chan, S.W., Lee, I., Song, H., Hong, W.
Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
Structure (2012) 20, 1135-1140. (revealed structural similarity of Vgll1-TEAD and YAP-TEAD complexes)
(highlighted by A*STAR research)

35. Zhu, D., Zhang, Y., Lam, P.P., Dolai, S., Liu, Y., Cai, E.P., Choi, D., Schroer, S.A., Kang, Y., Allister, E.M., Qin, T., Wheeler, M.B., Wang, C.C., Hong, W., Woo, M., Gaisano, H.Y.
Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth.
Cell Metabolism (2012) 16, 238-249. (highlighted by A-IMBN research)

36. Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L.S., Cai, L., Thompson, R.C., Yang, B., Chen, Y., Johnson, P.F., Wu, C., Bu, G., Mobley, W.C., Zhang, D., Gage, F.H., Ranscht, B., Zhang, Y.W., Lipton, S.A., Hong, W., and Xu, H.
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Nature Medicine
(2013) 19, 473-480. (with Cover image and  News and Views)



For complete list of publications, please click here


 

 
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