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Ng, R., Hussain, N.A., Zhang, Q.Y., Chang, C.W., Li, H.Y., Han, W.P., Stunkel, W. and Xu, F.* (2017)
miRNA-32 drives brown fat thermogenesis and trans-activates subcutaneous white fat browning in mice.
Cell Reports. 19, 1229–1246.

Julien, S.G., Kim, S.Y., Brunmeir, R., Sinnakannu, J.R., Ge, X.J., Ma, W., Yaligar, J., KN, B.P., Velan, S.S., Röder, P.V., Zhang, Q.Y., Sim, C.K., Wu, J.Y., Xie, W., McFarlane, C., Han, W.P. and Xu, F.* (2017)
Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.
PLoS Biology. 16;15(2):e1002597. (Research Highlights by Nature Reviews Endocrinology)

Brunmeir, R., Wu, J.Y., Peng, X., Julien, S.G., Zhang, Q.Y., Xie, W.* and Xu, F.* (2016)
Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.
PLoS Genetics. 12(12):e1006474.

Sim, C.K. #, Kim, S.Y. #, Brunmeir, R., Zhang, Q.Y., Li, H.Y., Dharmasegaran, D., Leong, C., Lim, Y.Y., Han, W.P. and Xu, F.* (2017) Regulation of White and Brown Adipocyte Differentiation by RhoGAP Dlc1.
PLoS One. 12(3):e0174761.

Li, N., Zhou, Z.S., Shen, Y., Xu, J., Miao, H.H., Xiong, Y., Xu, F., Li, B.L., Luo, J. and Song, B.L.* (2016)
Inhibition of the SREBP pathway suppresses hepatocellular carcinoma through repressing inflammation.
Hepatology. 2016 Dec 27.

Kim, S.Y. #, Sim, C.K. #, Zhang, Q.Y., Tang, H., Brunmeir, R., Pan. H., Karnani, N., Han, W.P., Zhang, K.L.* and Xu, F. * (2016)
An Alternative Strategy for Pan-acetyl- lysine Antibody Generation.
PLoS One. 11(9):e0162528.

Zheng H, Huang B, Zhang B, Xiang Y, Du Z, Xu Q, Li Y, Wang Q, Ma, J., Peng, X., Xu, F. and Xie, W.* (2016)
Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals.
Molecular Cell. 63(6):1066-79.

Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y., Peng, X., Ming, J., Wu, X., Zhang, Y., Xu, Q., Liu, W., Kou, X., Zhao, Y., He, W., Li, C., Chen, B., Li, Y., Wang, Q., Ma, J., Yin, Q., Kee, K., Meng, A., Gao, S., Xu, F., Na, J., and Xie, W.* (2016)
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.
Nature. 537(7621):553-557.

Wu. J., Huang, B., Chen. H., Yin, Q.Z., Li, W.Z., Liu. Y., Xiang, Y.L., Zhang. B.J., Zheng, H., Xia. W.K., Ming, J., Li, Y.Y., Zhang. W.H., Wang, Q.J., Zhang, J., Peng, X., Tian, G., Xu, F., Chang, Z., Yang, X.R., Na, J., and Xie, W.* (2016)
The landscape of accessible chromatin in mammalian preimplantation embryos.
Nature. 534(7609): 652-7.   

Sundaram, A., Hughes, T., Biondi, S., Bolduc, N., Bowman, S.K., Camilli, A., Chew, Y.C., Couture, C., Farmer, A., Jerome, J.P., Lazinski, D.W., McUsic, A., Peng, X., Shazand, K., Xu, F., Lyle, R.* and Gilfillan, G.D.* (2016)
A comparative study of ChIP-seq library preparation methods.
BMC Genomics. 17(1):816.

Kim, S.Y. #, Sim, C.K. #, Tang, H., Han, W.P., Zhang, K.L.* and Xu, F. * (2016) Acetylome study in mouse adipocytes identifies targets of SIRT1 deacetylation in chromatin organization and RNA processing.
Arch Biochem Biophys. 598:1-10.

Kim, S.Y. #, Sim, C.K. #, Tang, H., Han, W.P., Zhang, K.L.* and Xu, F. * (2015) Acetylome Analysis Identifies SIRT1 Targets in mRNA-processing and Chromatin- remodeling in Mouse Liver.
PLoS One. 10(10):e0140619.

Kim, S.Y., Zhang, Q.Y., Brunmeir, R., Han, W.P. and Xu, F. * (2015)
SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes.
PLoS One. 10(7):e0133448.

Joseph, R., Poschmann, J., Sukarieh, R., Too, P.G., Julien, S.G., Xu, F., Teh, A.L., Holbrook, J.D, Ng, K.L., Chong, Y.S., Gluckman, P.D., Prabhakar. S. and Stünkel, W.* (2015)
Acyl-CoA synthetase 1 in differentiated adipocytes from small for gestational age neonates: Putative association with fetal programming of cellular insulin sensitivity and lipid content.
Mol Endocrinol
. 29(6):909-920.

Peng, X., Wu, J.Y., Brunmeir, R., Kim, S.Y., Zhang, Q.Y., Ding, C.M., Han, W.P., Xie, W. and Xu, F. * (2015)
TELP, a sensitive and versatile library construction method for next-generation sequencing.
Nucleic Acids Res. 43(6):e35.

Nicholas, D., Tang, H., Zhang, Q.Y., Xu, F., Langridge, W. and Zhang, K.L.* (2015) Protein profiling reveals dynamic H1 expression and histone modifications during human monocyte differentiation.
Molecular and Cellular Proteomics. 14(1):15-29.

Yang, W.L., Thein, S., Lim, C.Y., Ericksen, R.E., Sugii, S., Xu, F., Robinson, R., Kim, J.B. and Han, W.P.* (2014)
Arp2/3 complex regulates adipogenesis by controlling cortical actin remodeling.
 Biochemical Journal. 464(2), 179-192.

Ramlee, M.K., Zhang, Q.Z., Idris, M., Peng, X., Sim, C.K., Han, W.P. and Xu, F. * (2014)
Histone H3 K27 acetylation marks a potent enhancer for the adipogenic master regulator gene Pparg2.
Cell Cycle. 13(21), 3414-3422.

Gao, M., Sim, C.K., Leung, C., Hu, Q.L., Feng, G.X., Xu, F.* Tang, B.Z.* and Liu, B.* (2014)
A fluorescent light-up probe for specific mitochondrial imaging to identify differentiating brown adipose cells.
Chemical Communications. 50(61), 8312-8315.

Yang, W.L., Thein, S., Wang, X.R., Bi, X.Z., Ericksen, R.E., Xu, F., and Han, W.P.* (2014) BSCL2 / seipin regulates adipogenesis through actin cytoskeleton remodeling.
Human Molecular Genetics. 23(2), 502-513.

Yang, W.L., Thein, S., Guo, X.X., Xu, F., Venkatesh, B., Sugii, S., Radda, G.K., and Han, W.P.* (2013)
Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus.
Biochemical Journal. 452, 37-44.

Villanueva, C.J., Vergnes, L., Drew, B., Tu, Y.P., Hu, Y., Peng, X., Xu, F., Saez, E., Wroblewski, K., Hevener, A., Reue, K., Fong, L.G., Young, S.G. and Tontonoz, P.* (2013)
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARg specifies lipid storage versus thermogenic gene programs.
Cell Metabolism. 17, 423–435.

Yang, W.L., Guo, X.X., Thein, S., Xu, F., Sugii, S., Baas, P.B., Radda, G.K., and Han, W.P.* (2013)
Regulation of adipogenesis by katanin-mediated cytoskeleton remodeling is facilitated by MEC-17-dependent acetylation of a-tubulin.
Biochemical Journal. 449, 605–612.

Zhang, Q.Y., Ramlee, M.K., Brunmeir, R., Villanueva, C.J., Halperin, D. and    Xu, F.* (2012)
Dynamic and distinct histone modifications modulate the expression of key adipogenesis regulatory genes.
Cell Cycle 11:23, 4310–4322.

Sun, W., Xie, W., Xu, F., Grunstein, M. and Li, K.C. (2009)
Dissecting nucleosome free regions by a segmental semi-Markov model.
PLoS One. 4(3):e4721.

Xie, W., Song, C., Young, N.L., Sperling, A.S., Xu, F., Sridharan, R., Conway, A.E., Garcia, B.A., Plath, K., Clark, A.T. and Grunstein, M. (2009)
Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.
Molecular Cell. 33, 417-427.

Xu, F., Zhang, Q.Y., Zhang, K.L., Xie, W. and Grunstein, M. (2007) Sir2 Deacetylates Histone H3 Lysine 56 to Regulate Telomeric Heterochromatin Structure in Yeast.
Molecular Cell. 27, 890-900.

Millar, C.B., Xu, F., Zhang, K.L. and Grunstein, M. (2006)
Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast.
Genes & Development. 20 (6), 711-722.

Xu, F., Zhang, K.L. and Grunstein, M. (2005)
Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast.
Cell. 121,375-385.

Yu, Y., Liu, Y., Shen, N., Xu, X., Xu, F., Jia, J., Jin, Y., Arnold, E. and Ding, J. (2004) Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity.
J Biol Chem. 279(9), 8378-8388.

Wang, Z.C., Wang, X.M., Jin, Y.X., Jiao, B.H., Xu, F., Miao, M.Y. and Zhu, K.J. Search for difference in aminoacylation of mitochondrial DNA-encoded wild-type and mutant human tRNALeu (UUR). (2003)
IUBMB Life
. 55(3), 139-144.

Xu, F., Jiang, G., Li, W., He, X., Jin, Y.X. and Wang, D. (2002)
Three G.C base pairs required for the efficient aminoacylation of tRNATrp by tryptophanyl-tRNA synthetase from Bacillus subtilis.
Biochemistry. 41(25), 8087-8092.

Jia, J., Xu, F., Chen, X., Chen, L., Jin, Y.X. and Wang, D.B. (2002)
Two essential regions for tRNA recognition in Bacillus subtilis tryptophanyl-tRNA synthetase.
Biochem J. 365(Pt 3), 749-756.

Xu, F., Chen, X.L., Xin, L., Chen, L., Jin, Y.X. and Wang, D.B. (2001)
Species- Specific Differences in the Operational RNA Code for Aminoacylation of tRNATrp.
Nucleic Acids Res. 29, 4125-4133.

Xu, F., Jia, J., Jin, Y.X. and Wang, D.B. (2001)
High-Level expression and single- step purification of human tryptophanyl-tRNA synthetase.
Protein Express. Purif. 23, 296-300.

Xu, R.H., Liu, J., Chen, X.W., Xu, F., Xie, Q., Yu, H., Guo, Q., Zhou, X.Q. and Jin, Y.X. (2001)
Ribozyme-mediated Inhibition of Caspase-3 Activity Reduces Apoptosis Induced by 6-Hydroxydopamine in PC12 Cells.
Brain Research. 899, 10-19.

 

 

 

 


 

 
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