Feng XU  
                       
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  Feng XU  
  Lab Location: #7-16

email:
fxu@imcb.a-star.edu.sg
tel: 6586 9678
 
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  Key Publications  
 

Ng, R., Hussain, N.A., Zhang, Q.Y., Chang, C.W., Li, H.Y., Han, W.P., Stunkel, W. and Xu, F.* (2017) miRNA-32 drives brown fat thermogenesis and trans-activates subcutaneous white fat browning in mice.
Cell Reports.
19, 1229–1246.
 
Julien, S.G., Kim, S.Y., Brunmeir, R., Sinnakannu, J.R., Ge, X.J., Ma, W., Yaligar, J., KN, B.P., Velan, S.S., Röder, P.V., Zhang, Q.Y., Sim, C.K., Wu, J.Y., Xie, W., McFarlane, C., Han, W.P. andXu, F.* (2017)
Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.
PLoS Biology.
16;15(2):e1002597. (Research Highlights by Nature Reviews Endocrinology)

Brunmeir, R., Wu, J.Y., Peng, X., Julien, S.G., Zhang, Q.Y., Xie, W.* and Xu, F.* (2016)
Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.
PLoS Genetics. 12(12):e1006474.

Zheng H, Huang B, Zhang B, Xiang Y, Du Z, Xu Q, Li Y, Wang Q, Ma, J., Peng, X., Xu, F.* and Xie, W.* (2016)
Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals. Molecular Cell. 63(6):1066-79.

Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y., Peng, X., Ming, J., Wu, X., Zhang, Y., Xu, Q., Liu, W., Kou, X., Zhao, Y., He, W., Li, C., Chen, B., Li, Y., Wang, Q., Ma, J., Yin, Q., Kee, K., Meng, A., Gao, S.,Xu, F., Na, J., and Xie, W.* (2016)
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature. 537(7621):553-557.

Wu. J., Huang, B., Chen. H., Yin, Q.Z., Li, W.Z., Liu. Y., Xiang, Y.L., Zhang. B.J., Zheng, H., Xia. W.K., Ming, J., Li, Y.Y., Zhang. W.H., Wang, Q.J., Zhang, J., Peng, X., Tian, G.,Xu, F., Chang, Z., Yang, X.R., Na, J., and Xie, W.* (2016) The landscape of accessible chromatin in mammalian preimplantation embryos.
Nature.
534(7609): 652-7.   

Peng, X., Wu, J.Y., Brunmeir, R., Kim, S.Y., Zhang, Q.Y., Ding, C.M., Han, W.P., Xie, W. andXu, F.* (2015)
TELP, a sensitive and versatile library construction method for next-generation sequencing. Nucleic Acids Res. 43(6):e35.  

Villanueva, C.J., Vergnes, L., Drew, B., Tu, Y.P., Hu, Y., Peng, X., Xu, F., Saez, E., Wroblewski, K., Hevener, A., Reue, K., Fong, L.G., Young, S.G. and Tontonoz, P.* (2013)
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARg specifies lipid storage versus thermogenic gene programs.
Cell Metabolism. 17, 423–435.

Xie, W., Song, C., Young, N.L., Sperling, A.S.,Xu, F., Sridharan, R., Conway, A.E., Garcia, B.A., Plath, K., Clark, A.T. and Grunstein, M. (2009)
Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.
Molecular Cell. 33, 417-427.

Xu, F., Zhang, Q.Y., Zhang, K.L., Xie, W. and Grunstein, M. (2007) Sir2 Deacetylates Histone H3 Lysine 56 to Regulate Telomeric Heterochromatin Structure in Yeast. Molecular Cell. 27, 890-900.

Millar, C.B.,Xu, F., Zhang, K.L. and Grunstein, M. (2006) Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast.
Genes & Development.
20 (6), 711-722.

Xu, F., Zhang, K.L. and Grunstein, M. (2005)
Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast.
Cell. 121,375-385.

 

 

 

 
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  Feng XU


Dr. Feng Xu has been a principal investigator in the Agency for Science, Technology and Research (A*STAR) since 2009, first at SICS and now at IMCB. He was trained as a chromatin biologist at the University of California, Los Angeles before establishing his lab in Singapore. His current research interest centers on the epigenetic regulation of energy balance. This topic includes the study of microRNAs, post-translational modifications on histones and non-histone metabolic regulators in the maintenance of metabolic homeostasis. His lab utilizes both advanced genomic tools as well as classic biochemistry and molecular biology techniques to tackle the scientific questions of interest. In addition, he is also interested in developing novel therapeutic approaches in treating metabolic disorders such as obesity and diabetes.

     
 

Epigenetic Regulation of Metabolic Homeostasis

 


Obesity and its related diseases such as diabetes increasingly are responsible for significant economic and social burdens in established and emerging countries. For instance, diabetes alone, is affecting more than 170 million people worldwide. As such, understanding the molecular mechanism that controls adipose (fat) cell differentiation would greatly enhance our ability to solve these problems. Adipogenesis is a complex physiological process that requires concerted regulation of gene expression by various adipogenic factors. Among these regulators are many histone modifying enzymes and chromatin remodelers, suggesting that epigenetic mechanisms play essential roles in modulating adipogenesis. In addition to histone modifications, microRNA represents another major group of epigenetic regulators involved in diverse physiological processes including adipogenesis. Our current research centers on the function of histone modifications and microRNAs in white adipocyte differentiation. And we are extending our research to the epigenetic control of brown adipocyte differentiation as well as lineage commitment from multipotent stem cells. To fully decipher the epigenetic mechanisms controlling adipogenesis and lineage commitment, we utilize the advanced genomic and proteomic methodologies as well as classic biochemistry and molecular biology techniques in our studies. Besides our basic research into the molecular mechanism of adipogenesis, we are also interested in identifying novel drug targets to treat obesity and metabolic diseases such as diabetes.