Ernesto GUCCIONE 
                       
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MDM4 exon6-inclusion is a widespread oncogenic mechanism and therapeutic target
Michael Dewaele*, Tommaso Tabaglio* , Karen Willekens* , Marco Bezzi*, Shun Xie Teo, Diana HP Low, Cheryl M Koh, […..] Jean-Christophe Marine# and Ernesto Guccione#
J Clin Invest., 2016 Jan #Corresponding Authors

Transcription and Imprinting Dynamics in Developing Postnatal Male Germline Stem Cells
Saher Sue Hammoud, Diana HP Low, Chongil Yi, Chee Leng Lee, Jon Oatley,
Christopher J. Payne, Douglas T. Carrell, Ernesto Guccione# and Bradley R. Cairns#
Genes Dev., 2015 Nov #Corresponding Authors

Regulation of the core pre-mRNA splicing machinery by MYC is essential to sustain lymphomagenesis
Cheryl M Koh*, Marco Bezzi*, Diana HP Low, Wei Xia Ang, Shun Xie Teo, Florence PH Gay, Muthafar Al-Haddawi, Soo Yong Tan, Motomi Osato, Arianna Sabò, Bruno Amati, Keng Boon Wee and Ernesto Guccione
Nature, 2015 Jul 2;523(7558):96-100

Telomerase subunit TERT regulates MYC dependent oncogenesis independent of its reverse transcriptase activity and role on telomeres
Cheryl M Koh*, Ekta Khattar*, Shi Chi Leow, Chia Yi Liu, Julius Muller, Wei Xia Ang, Yinghui Li, Guido Franzoso, Shang Li, Ernesto Guccione# and Vinay Tergaonkar#
J Clin Invest., 2015 May;125(5):2109-22. #Corresponding Authors

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.
Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, Morelli MJ, Bora P, Doni M,
Verrecchia A, Tonelli C, Fagà G, Bianchi V, Ronchi A, Low D, Müller H, Guccione E, Campaner S, Amati B
Nature, 2014 Jul 24;511(7510):488-92. Epub 2014 Jul 9.

Chromatin and transcription transitions of Mammalian adult germline stem cells and spermatogenesis.
Hammoud SS, Low DH, Yi C, Carrell DT, Guccione E#, Cairns BR#
Cell Stem Cell, 2014 Aug 7;15(2):239-53 #Corresponding Authors

Single-Cell Profiling of Epigenetic Modifiers Identifies PRDM14 as an Inducer of Cell Fate in the Mammalian Embryo
Burton A#, Muller J#, Tu S, Padilla-Longoria P, Guccione E*, Torres-Padilla ME*.
Cell Rep. 2013 Nov 14;5(3):687-701. *Corresponding Authors

Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish
Wang X, Zhao Z, Muller J, Iyu A, Khng AJ, Guccione E, Ruan Y, Ingham PW.
Biol Open. 2013 Sep 9;2(11):1203-13.

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 premRNA in sensing defects in the spliceosomal machinery
Bezzi M, Teo SX, Muller J, Mok WC, Sahu SK, Vardy LA, Bonday ZQ, Guccione E.
Genes Dev. 2013 Sep 1;27(17):1903-16

PRMT5 modulates the metabolic response to fasting signals.
Tsai WW, Niessen S, Goebel N, Yates JR 3rd, Guccione E, Montminy M.
Proc Natl Acad Sci U S A. 2013 May 13. [Epub ahead of print]
PMID: 23671120

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.
Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047.
PMID:23217706

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
Phalke S, Mzoughi S, Bezzi M, Jennifer N, Mok WC, Low DH, Thike AA, Kuznetsov VA, Tan PH, Voorhoeve PM, Guccione E.
Nucleic Acids Res. 2012 Oct;40(19):9534-42. doi: 10.1093/nar/gks858. Epub 2012 Sep 16.
PMID:22987071

Hairless promotes PPARγ expression and is required for white adipogenesis.
Kumpf S, Mihlan M, Goginashvili A, Grandl G, Gehart H, Godel A, Schmidt J, Müller J, Bezzi M, Ittner A, Guccione E, Wolfrum C, Ricci R.
EMBO Rep. 2012 Nov 6;13(11):1012-20. doi: 10.1038/embor.2012.133. Epub 2012 Sep 11.
PMID:22964757

On WD40 proteins: propelling our knowledge of transcriptional control?
Migliori V, Mapelli M, Guccione E.
Epigenetics. 2012 Aug;7(8):815-22. doi: 10.4161/epi.21140. Epub 2012 Jul 19. Review

miR-Sens--A retroviral dual-luciferase reporter to detect microRNA activity in primary cells.
Beillard E, Ong SC, Giannakakis A, Guccione E, Vardy LA, Voorhoeve PM.
2012, RNA.


Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Migliori V, Muller J, Phalke S, Low D, Bezzi M, Mok WC, Sahu SK, Gunaratne J, Capasso P, Bassi C, Cecatiello V, De Marco A, Blackstock W, Kuznetsov V, Amati B, Mapelli M, and Guccione E.
Nature Structural and Molecular Biology, January 2012.

Arginine/lysine-methyl/methyl switches: biochemical role of histone arginine methylation in transcriptional regulation
Migliori V, Phalke S, Bezzi M,
Guccione E.
Epigenomics,Volume 2, Number 1, February 2010, pp. 119-137(19)

Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a
Mariaelena Pistoni, Alessandro Verrecchia, Mirko Doni, Ernesto Guccione, and Bruno Amati.
EMBO J. 2010 Apr 7;29(7):1215-24. Epub 2010 Feb 18.

Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks.
Bua DJ, Kuo AJ, Cheung P, Liu CL, Migliori V, Espejo A, Casadio F, Bassi C, Amati B, Bedford MT, Guccione E, Gozani O.
PLoS One. 2009 Aug 26;4(8):e6789.

Smith AP, Verrecchia A, Fagà G, Doni M, Perna D, Martinato F, Guccione E, Amati B.
A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition.
Oncogene. 2009 Jan 22;28(3):422-30. Epub 2008 Nov 3.

Martinato F, Cesaroni M, Amati B, Guccione E.
Analysis of Myc-induced histone modifications on target chromatin.
PLoS ONE. 2008;3(11):e3650. Epub 2008 Nov 5.

Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, Lüscher B & Amati B.
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
Nature. 2007 Oct 18;449(7164):933-7

Gregorc U, Ivanova S, Thomas M, Guccione E, Glaunsinger B, Javier R, Turk V, Banks L, Turk B.
Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis.
Apoptosis. 2007 Feb;12(2):343-54.

Guccione E, Martinato F, Finocchiaro G, Luzi L, Tizzoni L, Dall’Olio V, Zardo G, Nervi C, Bernard L and Amati B.
Myc-binding-site recognition in the human genome is determined by chromatin context.
Nature Cell Biology. 2006 Jul;8(7):764-70. Epub 2006 Jun 11

Guccione E, Pim D, Banks L.
HPV-18 E6*I modulates HPV-18 full-length E6 functions in a cell cycle dependent manner.
Int J Cancer. 2004 Jul 20;110(6):928-33.

Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G.
The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.
J Mol Biol. 2004 May 28;339(2):313-25.

Guccione E, Lethbridge KJ, Killick N, Leppard KN, Banks L.
HPV E6 proteins interact with specific PML isoforms and allow distinctions to be made between different POD structures.
Oncogene. 2004 Jun 10;23(27):4662-72.

Thomas Laura R, Hepner K, Guccione E, Sawyers C, Lasky L, and Banks L.M,
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation.
Oncogene. 2002 Aug 1;21(33):5088-96. IF 6.495

Guccione E, Massimi P, Bernat A, and Banks L.
Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteins.
Virology. 2002 Feb 1;293(1):20-5.

Migliazza A, Bosch F, Komatsu H, Cayanis E, Martinotti S, Toniato E, Guccione E, Qu X, Chien M, Murty VV, Gaidano G, Inghirami G, Zhang P, Fischer S, Kalachikov SM, Russo J, Edelman I, Efstratiadis A, Dalla-Favera R.
Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.
Blood. 2001 Apr 1;97(7):2098-104.



 
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