(A) A ribbon diagram of the TEAD4-YAP complex. TEAD4 and YAP are shown in green and pink, respectively, and the PXXΦP motif in YAP is colored in cyan. Secondary structure for both TEAD4 and YAP are marked.
(B) Surface view of TEAD4 (green) with bound YAP in ribbon diagram (pink with the PXXΦP motif in cyan). The view is as in (A).
(C) Residues in TEAD4 involved in interactions with YAP are important for anchorage-independent cell growth.
(D) The PXXΦP containing loop of YAP is essential for TEAD4 interaction as well as for the transforming activity of YAP.
Published in Genes and Development, 2010 Feb 1;24(3):290-300
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