IMCB congratulates Steve Cohen on being awarded a 2-year grant for US$ 499,885. This grant will support Prof. Cohen’s research team as they systematically survey the fly genome for microRNAs linked to neurodegeneration.
Advances made with microRNAs in animal models should set the stage to explore new causes of human neurodegenerative diseases. By harnessing the power of Drosophila genetics for a systematic survey of microRNA mutations causing neurodegeneration, Prof. Cohen’s team will seek to uncover the genomic repertoire of potential causes of the cellular defects that underlie disease.
They aim to complete a series of assays to determine if misregulated or mutated microRNAs expressed in the brain lead to neurodegenerative defects and other pathologies. The hope is to not only uncover new therapeutic approaches to neurodegenerative disease, but also to pinpoint new disease mechanisms and spawn the development of new disease models in laboratory animals, including mouse.
Figure Legend: Image of a 3rd instar larval fly CNS labelled to show neurons and glial cells.
For more information on Prof. Steve Cohen’s laboratory, please click here.