Philip W. Ingham* ‡, Yoshiro Nakano* § and Claudia Seger*
* Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673.
‡ Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543.
§ Department of Genetics, Hyogo College of Medicine,1‑1 Mukogawa-cho, Nishinomiya, Hyogo 663‑8501, Japan.
Published in Nature Rev Genetics, 19 April 2011. (Epub ahead of print.)
Hedgehog proteins constitute one of a small number of families of secreted signals that have a central role in the development of metazoans. Genetic analyses in flies, fish and mice have uncovered the major components of the pathway that transduces Hedgehog signals, and recent genome sequence projects have provided clues about its evolutionary origins. In this Review we provide an updated overview of the mechanisms and functions of this signalling pathway, highlighting the conserved and divergent features of the pathway, as well as some of the common themes in its deployment that have emerged from recent studies.