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  current news   Press   selected story    
     
  5th May 2011  
 

Mechanisms and functions of Hedgehog signalling across the Metazoa.

 
 




Authors
Philip W. Ingham* ‡, Yoshiro Nakano* § and Claudia Seger*

*  Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673.
‡  Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543.
§  Department of Genetics, Hyogo College of Medicine,1‑1 Mukogawa-cho, Nishinomiya, Hyogo 663‑8501, Japan.

Published in Nature Rev Genetics, 19 April 2011. (Epub ahead of print.)

Abstract
Hedgehog proteins constitute one of a small number of families of secreted signals that have a central role in the development of metazoans. Genetic analyses in flies, fish and mice have uncovered the major components of the pathway that transduces Hedgehog signals, and recent genome sequence projects have provided clues about its evolutionary origins. In this Review we provide an updated overview of the mechanisms and functions of this signalling pathway, highlighting the conserved and divergent features of the pathway, as well as some of the common themes in its deployment that have emerged from recent studies.

 
 

 
 


Figure Legend: The Hh signaling protein was originally identified in Drosophila (upper panel) where it is expressed and secreted (green dots) by cells at the boundary of each embryonic segment (red staining): it was subsequently found to be highly conserved in zebrafish (lower panel) and other vertebrates where its expression in the notochord and ventral neural tube (green signal) controls patterning of the central nervous system.

For more information on Philip INGHAM’s laboratory, please click here.