Figure Legend: Sequence comparison of various members of the Snail superfamily.
a) Overall structure of Snail superfamily members including the relative positions of the SNAG domain, zinc fingers (I–V), as well as the Scratch- and Slug-specific boxes. b) Consensus sequences of the different zinc fingers for Snail (Sna; light purple), Scratch (Scrt; green) and the whole Snail superfamily (dark purple). c, d) Sequence comparison of the Slug and Scratch specific domains respectively across various organisms. (Dm, Drosophila melanogaster; Dr, Danio rerio; Gg, Gallus gallus; Hs, Homo sapiens; Mm, Mus musculus; Xl, Xenopus laevis) e) Sequences of the SNAG domain present in representative members of the three big groups of bilateralians. (Bf, Brachiostoma floridae; Lv, Lytechinus variegatus; Pv, Patella vulgate) The zinc-finger region and the SNAG domain have been shown to be fundamental for protein function, while the domains specific for Slug and Scratch allow the classification of these members into their assigned subfamilies. (Adapted from Nature Review Molecular Cell Biology 2002; 3: 455-466)
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